ArticleMovement disorders : official journal of the Movement Disorder Society2025
Reliability of Neuroimaging and Neurophysiological Tremor Features in Parkinson's Disease.
Article in Movement disorders : official journal of the Movement Disorder Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Neurophysiological Basis of Tremor Disorders: Parkinson's Disease, Essential Tremor, Tremor in Dystonia, and Holmes Tremor.Seminars in neurology · 2026Review
- Temporal Dynamics of Parkinson's Disease Tremor: Clinical and Neuroimaging Insights.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- A Distributed Oscillatory Network Model of Parkinsonian Tremor: Integrating Basal Ganglia and Cerebello-Thalamic Circuits.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Review
- Differential brain iron deposition in Parkinson's disease subtypes: a comparative quantitative susceptibility mapping study of tremor-dominant versus postural instability/gait difficulty phenotypes.Frontiers in neurologyArticle
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Authors and funding
6 authors.
Funding
Abstract
backgroundTremor is one of the cardinal motor symptoms of Parkinson's disease (PD). Its severity can be quantified with clinical rating scales and neurophysiology. The pathophysiology of PD tremor involves activity in the cerebello-thalamo-cortical circuit (CTC), which can be quantified with concurrent accelerometry-functional magnetic resonance imaging (fMRI). This opens possibilities for fMRI-informed precision medicine, but it remains unclear if tremor-related fMRI activity is a reliable biomarker at the individual level.
objectivesTo assess the test-retest reliability of three PD tremor outcome measures: clinical rating scales, accelerometry, and combined accelerometry-fMRI.
methodsWe studied 26 tremor-dominant PD patients OFF medication on two separate days (2-month interval). On each day, tremor was characterized with clinical rating scales (Fahn-Tolosa-Marin Tremor Rating Scale), accelerometry, and concurrent accelerometry-fMRI. Reliability was assessed using Spearman correlations and intraclass correlation coefficients.
resultsClinical and neurophysiological tremor parameters were reliable across sessions. Resting tremor-related fMRI activity was observed within the CTC across both sessions. The amplitude of tremor-related activity in motor cortex and cerebellum had a significant, but moderate, between-session reliability. Furthermore, the activity-by-voxel distribution of tremor-related activity within motor cortex and cerebellum showed a significant between-session correlation in at least two-thirds of patients, and intra-individual variability was significantly lower than inter-individual variability.
conclusionsBoth the amplitude and location of resting tremor-related activity in motor cortex and cerebellum, derived from concurrent accelerometry-fMRI, are replicable between sessions. This suggests that accelerometry-fMRI may be used as an individual biomarker for tremor pathophysiology, to guide intervention studies and assess target engagement of new anti-tremor therapies. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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