ArticleScience progress
Higher expression of high-mobility group box 1 in cholangiocarcinoma and association with cell growth, in vitro migration and invasion, and chemo-drug sensitivity.
Article in Science progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- HMGB1 directly activates BAP1 transcription to sustain tumor growth in mesothelioma.Cell death and differentiation · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ObjectiveCholangiocarcinoma is a lethal malignancy with an increasing incidence and mortality worldwide. Numerous studies have indicated that high-mobility group box 1 is associated with cancer progression. The modulation of subcellular high-mobility group box 1 expression is a major cause of chemotherapeutic drug resistance. This study aimed to demonstrate the role of high-mobility group box 1 in cholangiocarcinoma, including proving the concept of high-mobility group box 1 expression in patients with cholangiocarcinoma, cancer cell growth, migration, invasion, and the modulation of chemotherapeutic drug sensitivity in cholangiocarcinoma cells.MethodsTwenty paraffin-embedded tissue samples were analyzed for high-mobility group box 1 expression using immunohistochemistry. High-mobility group box 1 expression was silenced in KKU-213AL5 cells through siRNA transfection, followed by in vitro assays to assess cell proliferation, migration, invasion, and drug sensitivity. Furthermore, the role of high-mobility group box 1 in regulating growth and metastasis-related signaling pathways was investigated using immunoblotting and protein-protein interaction analysis.ResultsThe results showed that high-mobility group box 1 was highly expressed in cholangiocarcinoma tissues compared to adjacent tissues (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.