Evidence map›Paper›PMID 40686431›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

A Subcircuit in the Suprachiasmatic Nucleus Generates Wakefulness.

Qiang Liu, Sang Soo Lee, Jiali Xiong, Shahin Ahmadi, Benjamin J Bell, Mehmet F Keles, Mark N Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. A direct SCN-to-DMH output pathway organizes circadian behavioral timing.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. A Subcircuit in the Suprachiasmatic Nucleus Generates Wakefulness.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qiang LiuDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.ORCID https://orcid.org/0009-0000-6979-066X
Sang Soo LeeDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Jiali XiongBiochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Shahin AhmadiDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Benjamin J BellDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Mehmet F KelesDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Mark N WuDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.ORCID https://orcid.org/0000-0002-1329-0655

Funding

Cross-Species Analyses of the Molecular and Circuit Basis ofSleepR35NS122181 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Mark N Wu · 2021 to 2026
$6.9M
Molecular and Cellular Mechanisms Underlying the Circadian Timing of SleepR01NS094571 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WU, MARK N · 2016 to 2020
$2.5M
National Institutes of Health: R35NS122181NIH HHS R01NS094571NINDS NIH HHS R01 NS094571NINDS NIH HHS R35 NS122181Sleep Research Society Foundation: Career Development Award
6 · The paper itself

Abstract

The daily cycles of sleep and arousal are among the most prominent biological rhythms under circadian control. While the role of the suprachiasmatic nucleus (SCN) as the master circadian pacemaker is well-established, the molecular and circuit mechanisms by which it regulates the rhythms of sleep and arousal remain poorly understood. It has previously shown that the Drosophila clock-output molecule Wide Awake (WAKE) and its mammalian homolog mWAKE are expressed in fly clock neurons and dorsomedial hypothalamus neurons that promote arousal. Here, it is investigated whether mWAKE labels an arousal-promoting SCN subcircuit in mice. Broad chemogenetic activation and inhibition of mWAKE

Indexed as

Circadian RhythmSuprachiasmatic NucleusWakefulnessAnimalsArousalCircadian ClocksMaleMiceNeuronsSleeparousalcircadianmWAKESCNsleep

Identifiers

PMID40686431
PMCPMC12533371

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.