Evidence map›Paper›PMID 40686349›Full record

ArticleMuscle & nerve2025

Motor Unit Number Index (MUNIX) in Control Children: Reference Values and Reliability.

Christophe Boulay, Emilien Delmont, Frédérique Audic, Cécile Halbert, Sébastien Pesenti, Brigitte Chabrol, Béatrice Desnous, Shahram Attarian

Abstract read
In one paragraph

Article in Muscle & nerve, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christophe BoulayReference Center for Neuromuscular Diseases and ALS Timone University Hospital, Aix-Marseille University, Marseille, France.ORCID https://orcid.org/0000-0001-8749-6341
Emilien DelmontReference Center for Neuromuscular Diseases and ALS Timone University Hospital, Aix-Marseille University, Marseille, France.ORCID https://orcid.org/0000-0002-5591-2774
Frédérique AudicReference Center for Neuromuscular Diseases and ALS Timone University Hospital, Aix-Marseille University, Marseille, France.
Cécile HalbertReference Center for Neuromuscular Diseases and ALS Timone University Hospital, Aix-Marseille University, Marseille, France.
Sébastien PesentiGait Laboratory, Pediatric Orthopaedic Surgery Department, Timone Children Hospital, Marseille, France.
Brigitte ChabrolReference Center for Neuromuscular Diseases and ALS Timone University Hospital, Aix-Marseille University, Marseille, France.
Béatrice DesnousNeuropediatric Department, Children Timone University Hospital, Aix-Marseille University, Marseille, France.
Shahram AttarianReference Center for Neuromuscular Diseases and ALS Timone University Hospital, Aix-Marseille University, Marseille, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

INTRODUCTION/

aimsThe motor unit number index (MUNIX) is recognized as a reliable electrophysiological biomarker, and reference values are available for healthy adults but not for children. The aim of this study was to determine reference MUNIX values in healthy children.

methodsSixty control children (28 females) were grouped as under 5 years (n

resultsThe APB MUNIX increased by 6.5 [95% confidence interval, 3.2-9.7] per year of age, 1.0 [0.5-1.5] per cm, and 1.7 [0.4-4.0] per kg (p < 0.001 in each case), but was not independently associated with either of these three variables in multivariable analysis. The APB compound muscle action potential (CMAP) increased by 0.42 [0.30-0.52] per year of age, 0.06 [0.04-0.08] per cm, and 0.11 [0.07-0.14] per kg (p < 0.001 in each case), and increased with age independently of height and weight at borderline significance (p = 0.065). Measurement reproducibility was high for the experienced investigator, but lower between the experienced and the inexperienced investigator. DISCUSSION: The high intra-investigator reproducibility for the experienced investigator indicates that these parameters are useful electrophysiological biomarkers for disease progression and potential treatment response.

Indexed as

Action PotentialsMotor NeuronsMuscle, SkeletalAdolescentAge FactorsChildChild, PreschoolElectromyographyFemaleHumansMaleReference ValuesReproducibility of ResultsbiomarkerCMAPcontrol childrenMUNIXMUSIX

Identifiers

PMID40686349
PMCPMC12435161

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.