ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Stiffness-Tunable Neurotentacles for Minimally Invasive Implantation and Long-Term Neural Activity Recordings.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Multifunctional material platforms for neural interfaces: active orchestration of dynamic foreign body response across implantation lifetimes.Bioactive materials · 2026Review
- Sb-TiORSC advances · 2026Article
- A Comb-Shaped Flexible Microelectrode Array for Simultaneous Multi-Scale Cortical Recording.Micromachines · 2026Article
- Multifunctional Composite Coating-Enhanced Flexible Microelectrodes for Chronic, High-Fidelity Neural Signal Recording.Analytical chemistry · 2025Article
- Stiffness-Tunable Neurotentacles for Minimally Invasive Implantation and Long-Term Neural Activity Recordings.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Flexible microelectrodes are ideal for chronic neural recordings; however, their low bending strength poses challenges during probe insertion. Here, a stiffness-tunable polyimide probe, termed Neurotentacle, is proposed for deep brain implantation. Its tunability is enabled by embedded microchannels with controllable liquid pressure. During insertion, the Neurotentacle becomes stiff under elevated internal pressure, allowing penetration of brain tissue without additional materials or tools. Once inserted, it regains flexibility by reducing the internal pressure. The novel ultra-thin microchannel fabrication technique enables the Neurotentacle to maintain dimensions similar to conventional flexible probes. This minimizes tissue damage during insertion while ensuring long-term biocompatibility and stability, confirmed by histological evaluations in both acute and chronic animal models. In long-term recordings, Neurotentacles outperform traditional shuttle-assisted implantation methods. The technique is straightforward, controllable, and does not require complex devices, making it ideal for minimally invasive implantation and long-term neural recordings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.