Evidence map›Paper›PMID 40686338›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Counterbalancing O-GlcNAcylation and STAT3 Phosphorylation in Ventral Tegmental Area Dopaminergic Neurons Mediates Behavioral Adaptations to Acute Restraint Stress.

Mingshuo Shao, Yi Wu, Haiyang Wang, Chenchun Zhang, Ying Zhu, Yan Jiang, Changyou Jiang, Qiumin Le, Xing Liu, Lan Ma and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mingshuo ShaoSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, and Institutes of Brain Science, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200032, China.
Yi WuSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, and Institutes of Brain Science, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200032, China.
Haiyang WangSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, and Institutes of Brain Science, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200032, China.
Chenchun ZhangSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, and Institutes of Brain Science, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200032, China.
Ying ZhuSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, and Institutes of Brain Science, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200032, China.
Yan JiangSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, and Institutes of Brain Science, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200032, China.
Changyou JiangSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, and Institutes of Brain Science, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200032, China.
Qiumin LeSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, and Institutes of Brain Science, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200032, China.
Xing LiuSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, and Institutes of Brain Science, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200032, China.
Lan MaSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, and Institutes of Brain Science, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200032, China.
Feifei WangSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, and Institutes of Brain Science, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200032, China.ORCID https://orcid.org/0000-0002-2351-6873

Funding

CAMS Innovation Fund for Medical Sciences 2021-I2M-5-009Natural Science Foundation of China 32171041Natural Science Foundation of China 32222033Natural Science Foundation of China 32270660Natural Science Foundation of China 32271064Natural Science Foundation of China 32330041Natural Science Foundation of China 32450102Natural Science Foundation of China 82021002Shanghai Rising-Star Program 23QA1401500STI2030-Major Projects 2021ZD0202100STI2030-Major Projects 2021ZD0203500STI2030-Major Projects 2022ZD0214500
6 · The paper itself

Abstract

Acute stressors, significant risk factors for mood disorders, increase anxiety and reduce reward sensitivity. However, the underlying neuroadaptive mechanisms remain unclear. Here, it is shown that acute restraint stress upregulates Signal Transducer and Activator of Transcription 3 (STAT3) signaling and O-GlcNAcylation in ventral tegmental area (VTA) dopaminergic (DAergic) neurons. Multi-omics analyses in O-linked N-acetylglucosamine transferase (OGT) conditional knockout (cKO) mice reveal a counterbalancing mechanism between O-GlcNAcylation and STAT3

Indexed as

Dopaminergic NeuronsSTAT3 Transcription FactorStress, PsychologicalVentral Tegmental AreaAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutN-AcetylglucosaminyltransferasesPhosphorylationRestraint, PhysicalN-AcetylglucosaminyltransferasesStat3 protein, mouseSTAT3 Transcription Factordopaminergic neuronsemotionpost‐translational modificationsSTAT3stress

Identifiers

PMID40686338
PMCPMC12533289

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.