ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
A Blast-Resistant NLR Gene Confers Drought Resistance by Competitively Interacting with an E3 Ligase to Protect Phenylalanine Ammonia-Lyase in Rice.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Functional analysis of down-regulated CYP6AE gene clusters involved in the insecticidal mechanism of lycorine against Spodoptera litura.Pest management science · 2026Article
- SDR3.1 negatively regulates seed dormancy in Poaceae crops.The Plant journal : for cell and molecular biology · 2026Article
- An LRR-truncated NLR natural variant confers dual resistance to drought and blast in rice.Nature communications · 2026Article
- Genome-wide analysis and expression profiling of the phenylalanine ammonia-lyase gene family in Chrysanthemum morifolium.BMC plant biology · 2026Article
- Genetic coupling of leaf and kernel-related traits shapes drought adaptation in maize.The Plant journal : for cell and molecular biology · 2026Article
- De Novo Chromosome-Level Genome Assembly of 'Qing Zhou Mi' Landrace Peach and Analysis of Late Maturity and Fruit Weight Traits in Peach.Plants (Basel, Switzerland) · 2026Article
- Comprehensive characterization of safflower cytochrome P450 family and the role of CtCYP41 in flavonoid biosynthesis and drought response.BMC plant biology · 2026Article
- Genome-Wide Association Study Reveals Genetic Loci, Candidate Genes and Favorable Haplotypes for Important Agronomic Traits inJournal of fungi (Basel, Switzerland) · 2026Article
- Transcriptomics and non-targeted metabolomics reveal the mechanisms of leaf color changes in red-leaf cotton under drought stress and rewatering.Frontiers in plant science · 2026Article
- Phenylalanine Ammonia-Lyase: A Core Regulator of Plant Carbon Metabolic Flux Redistribution-From Molecular Mechanisms and Growth Modulation to Stress Adaptability.Plants (Basel, Switzerland) · 2025Review
- A Blast-Resistant NLR Gene Confers Drought Resistance by Competitively Interacting with an E3 Ligase to Protect Phenylalanine Ammonia-Lyase in Rice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
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18 authors.
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Abstract
Drought and diseases represent major challenges to achieve high yield in crops, underscoring the urgent need to explore drought- and disease-resistant genetic resources and breed crop varieties with multi-stress resistance. Here, using a genome-wide association study combined with function analyses, PibH8, a homologous of the blast resistance gene Pib encoding a nucleotide-binding leucine-rich repeat receptor (NLR) is identified, which plays a crucial role in rice drought resistance. PibH8 interacts with phenylalanine ammonia-lyase OsPAL1, a rate-limiting enzyme in phenylpropanoids biosynthesis pathway in rice. It protects OsPAL1 from degradation by competitively binding to E3 ubiquitin ligase OsFBK16, which facilitates OsPAL1 degradation. This protective mechanism enhances PAL activity, leading to increased lignin and flavonoids content and improved drought resistance. Genetic evidence indicates that PibH8 acts upstream of OsPAL1 in conferring drought resistance. Furthermore, a causal variation in the PibH8 promoter that is associated with drought resistance is identified. Introgression of a superior haplotype, which exhibits high PibH8 expression, into the elite rice variety Kongyu131 significantly improved drought and blast resistance. This research not only elucidates a regulatory mechanism of NLR protein in drought resistance, but also highlights a promising breeding value of PibH8 for simultaneously improving drought and blast resistance.
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