Evidence map›Paper›PMID 40686276›Full record

ArticleInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences2025

4D flow MRI for noninvasive monitoring of high-flow vascular malformations in neonates and infants: A feasibility study.

Jonathan A Massachi, Christopher Yoo, Sartaaj Walia, Jonas Schollenberger, David Saloner, Helen Kim, Christine K Fox, Heather J Fullerton, Steven W Hetts, Kazim H Narsinh

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Article in Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Jonathan A MassachiDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-8645-5740
Christopher YooDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-4694-3886
Sartaaj WaliaDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Jonas SchollenbergerDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
David SalonerDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Helen KimDepartment of Anesthesiology, University of California San Francisco, San Francisco, CA, USA.
Christine K FoxDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Heather J FullertonDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Steven W HettsDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-5885-7259
Kazim H NarsinhDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-2019-5461

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundIntracranial high-flow vascular malformations greatly alter neonatal cerebral hemodynamics and can cause significant morbidity and mortality. X-ray digital subtraction angiography (DSA) is the standard of care to assess angioarchitecture and plan for intervention, but exposes patients to radiation and procedural risks, and only allows for subjective interpretation. Objective noninvasive assessment of hemodynamics could improve prognostication. Data on normal or abnormal cerebral hemodynamics in neonates is limited due to the lack of readily available and validated methods. 4D flow MRI may offer noninvasive quantitative assessment of hemodynamic metrics to gain a better understanding of pathophysiology and may one day help to guide endovascular intervention. Here, we explore the feasibility of 4D flow MRI for the assessment of high-flow vascular malformations and present our initial experience.MethodsRetrospective analysis of 4D flow MRI studies was performed for five children with high-flow vascular malformations before and/or after embolization of their lesions. Two raters independently performed the 4D flow measurements: flow rate and peak speed. We compared quantitative measurements with qualitative angiographic findings.ResultsInterrater reliability of flow measurements was high (intraclass correlation coefficient 0.959). Quantitative changes in arterial and venous 4D flow measurements after embolization corresponded with qualitative changes on DSA.Conclusions4D flow MRI is a feasible and precise tool for studying high-flow intracranial vascular malformations in children with safety advantages over DSA. Standardized acquisition protocols and postprocessing methods could facilitate adoption across multiple centers.

Indexed as

4D flowhigh-flow vascular malformationMRIpediatricvein of Galen malformation

Identifiers

PMID40686276
PMCPMC12279767

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.