ArticleJournal of pediatric gastroenterology and nutrition2025
Noninvasive monitoring with bowel ultrasound (NIMBUS) in paediatric inflammatory bowel disease: Feasibility in a single centre.
Article in Journal of pediatric gastroenterology and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05673278 (To Examine the Feasibility of Non-Invasive Monitoring With Bowel Ultrasound in Paediatric Inflammatory Bowel Disease and Correlation With Inflammatory Markers, Disease Activity Scores and as a Predictor of Changes in Treatment), which is not on this map. Cited by 1 paper.
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To Examine the Feasibility of Non-Invasive Monitoring With Bowel Ultrasound in Paediatric Inflammatory Bowel Disease and Correlation With Inflammatory Markers, Disease Activity Scores and as a Predictor of Changes in Treatment (NIMBUS)
Who cites it
1 citing paper in PubMed.
- Noninvasive monitoring with bowel ultrasound (NIMBUS) in paediatric inflammatory bowel disease: Feasibility in a single centre.Journal of pediatric gastroenterology and nutrition · 2025Article
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Authors and funding
7 authors.
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Abstract
objectivesBowel ultrasound (BUS) is increasingly utilised for monitoring inflammatory bowel disease (IBD), a condition with stringent treatment targets to prevent complications. This study assessed the feasibility of BUS in paediatric IBD and its correlation with established monitoring markers.
methodsA prospective study was conducted at a specialist paediatric IBD centre, including children aged 2-18 years with IBD diagnosed via modified Porto criteria. BUS parameters were based on paediatric ultrasound scoring systems, with imaging performed by a single paediatric radiologist. Biomarker data (faecal calprotectin, C-Reactive Protein, Erythrocyte Sedimentation Rate, White Cell Count, Ferritin and Albumin), and paediatric disease activity indices were recorded at time of BUS and again after a median follow-up of 2.8 months (interquartile range 1.8-4.1). Treatment changes were recorded, and ultrasound findings were correlated with clinical outcomes and inflammatory markers.
resultsForty patients were included, 27 with ulcerative colitis (UC) or UC-type IBD-unclassified. BUS was feasible, with 98% retention (n = 39) and 96.5% measurable parameters (301/312). Poor-quality imaging occurred in 10.3%. In UC, bowel wall thickness (BWT, rho = 0.503, p = 0.039) and loss of haustration (rho = 0.490, p = 0.039) correlated with faecal calprotectin; no correlations were found for Crohn's disease or the total cohort. Activity index scores did not correlate with BUS parameters.
conclusionsBUS shows potential as a noninvasive tool for assessing IBD activity in paediatric patients, especially in colitis where BWT correlates with calprotectin. However, image acquisition challenges highlight the need for expertise. Further studies across diverse cohorts are necessary to establish BUS's utility in paediatric IBD monitoring. CLINICAL
trial registrationClinicaltrials.gov (21/12/2022): NCT05673278, https://clinicaltrials.gov/study/NCT05673278, IRAS ID: 8497/OCT/2022, Date of first enrolment: 01/05/2023.
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