Evidence map›Paper›PMID 40686204›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Mucociliary Clearance Inspired Nanozyme-centric Hydrogel Composites for Integrated Bacterial Detection.

Zhaoling Tan, Xuejiao Wang, Zhaoyue Wang, Jieke Jiang, Xi Yao

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhaoling TanDepartment of Biomedical Sciences, City University of Hong Kong, Kowloon, Hong Kong SAR, 999077, P. R. China.ORCID https://orcid.org/0009-0009-7376-9666
Xuejiao WangDepartment of Biomedical Sciences, City University of Hong Kong, Kowloon, Hong Kong SAR, 999077, P. R. China.
Zhaoyue WangShenzhen Research Institute of City University of Hong Kong, Shenzhen, 518057, P. R. China.
Jieke JiangMedicine center for PanorOmic Sciences, University of Hong Kong, Pokfulam, Hong Kong SAR, P. R. China.
Xi YaoDepartment of Biomedical Sciences, City University of Hong Kong, Kowloon, Hong Kong SAR, 999077, P. R. China.ORCID https://orcid.org/0000-0001-8986-3571

Funding

Guangdong Basic Research Program 2025A1515011479IDM Project 9229501-14-YXResearch Grant Council of Hong Kong CityU11307220Research Grant Council of Hong Kong CityU11307721Shenzhen Basic Research Program JCYJ20240813153107010
6 · The paper itself

Abstract

The rapid movement of populations has led to the transmission and infection of pathogens, imposing a significant burden on global healthcare systems and economies. Despite considerable progress, current strategies heavily rely on specialized instruments or complex processing of bacterial samples. Inspired by pulmonary cilia and the mucus on it, a nanozyme-centric hydrogel network, integrated into nanowires for comprehensive bacterial lysis and detection. Nanozymes serve as multifunctional initiators and crosslinkers for the hydrogel network, enabling a one-step gelation process that addresses the aggregation issues of nanozyme particles, and improving the sensitivity of colorimetric detection. By integrating the nanozyme-centric hydrogel with the rapid piercing capabilities of the nanowire arrays, an efficient platform is developed for the disinfection, lysis, and detection of various bacterial strains. Moreover, this detection platform is adaptable to flexible substrates and can be integrated with machine learning algorithms, promoting versatile home-based pathogen testing in resource-limited settings.

Indexed as

BacteriaHydrogelsMucociliary ClearanceHumansNanowiresHydrogelsbacteria biosensinghydrogelnanowirenanozymepoint‐of‐care detection

Identifiers

PMID40686204
PMCPMC12463100

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.