ArticleJournal of cosmetic dermatology2025
Recombinant Type III Humanized Collagen Solution for Injection Improves Skin Photoaging in Chinese Population: A Case Series.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Effectiveness and Safety of Recombinant Type III Humanized Collagen Solution Injection Combined With Collagen-III Multi-Peptide Serum in Improving Signs of Photoaging: A Prospective, Split-Face Controlled Clinical Trial.Journal of cosmetic dermatology · 2026Trial
- Translational Application of Recombinant Humanized Type III Collagen in Facial Rejuvenation: A Randomized Controlled Trial.Journal of cosmetic dermatology · 2025Trial
- Age-Associated Differences in Facial Skin Structure in Chinese Women: a Cross-Sectional Study.Dermatology and therapy · 2026Article
- Assessment of Subepidermal Low-Echogenic Band via High-Frequency Ultrasound for Evaluating the Efficacy of Platelet-Rich Plasma Injection in Treating Facial Skin Photoaging: A Case Series.Journal of cosmetic dermatology · 2026Article
- Correction to "Recombinant Type III Humanized Collagen Solution for Injection Improves Skin Photoaging in Chinese Population: A Case Series".Journal of cosmetic dermatology · 2025Article
- Recombinant Type III Humanized Collagen Solution for Injection Improves Skin Photoaging in Chinese Population: A Case Series.Journal of cosmetic dermatology · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhotoaging leads to structural changes in the skin, such as reduced collagen production, contributing to wrinkles, reduced elasticity, and dyspigmentation. Collagen-based treatments have shown promise in skin rejuvenation, but the effectiveness of recombinant type III humanized collagen (RhCol-III) solution for injection in Asian populations has not been widely studied.
aimsTo evaluate the efficacy of RhCol-III solution injections in improving skin quality for rejuvenation among Chinese cases.
methodsEight Chinese participants with Fitzpatrick phototype III/IV, presenting with signs of skin photoaging, underwent once a month intradermal injections of 2 mg/mL RhCol-III solution over a 90-day period. Clinical assessments, including VISIA imaging, ultrasound, cutometer, and self-assessed Global Aesthetic Improvement Scale (GAIS) scores, were conducted at baseline, 30, 60, and 90 days postinjection. Key skin parameters such as elasticity, firmness, wrinkle severity, pigmentation, and pore size were evaluated to assess the effectiveness of the RhCol-III solution.
resultsParticipants demonstrated significant improvements in skin quality, although variable due to individual response. VISIA imaging indicated enhanced skin tone evenness and radiance. Participants who had visible wrinkle reduction and pore size decrease, on further assessment, were found to have increased dermal thickness and density, along with improved skin elasticity and firmness. Most participants reported high levels of satisfaction with the treatment outcomes, and no significant adverse events were observed.
conclusionsRhCol-III solution injections appear to be a safe and effective treatment for skin rejuvenation, offering improvements in elasticity, firmness, skin tone, and radiance. This case series brings out the potential of RhCol-III solution in providing substantial anti-photoaging benefits in Chinese facial skin.
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