ArticleJournal of cosmetic dermatology2025
Dermatologically Tested Apple-Derived Extracellular Vesicles: Safety, Anti-Aging, and Soothing Benefits for Skin Health.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Decoding Cyclodextrins in Skin Applications: Structure, Mechanisms, and Safety in Cosmetic and Dermatologic Formulations (Part I).International journal of molecular sciences · 2026Review
- Apple-Derived Vesicles Orchestrate Bone Regeneration:International journal of molecular sciences · 2026Article
- Efficacy of Exosome-Based Therapies for Skin Rejuvenation: A Systematic Review of Human Studies.Cureus · 2026Review
- Plant-derived extracellular vesicles for drug delivery: current and future.Regenerative biomaterials · 2026Review
- Research Progress and Preclinical Prospects of Plant-Derived Extracellular Vesicles in Targeted Delivery of Antitumor Drugs.International journal of nanomedicine · 2026Review
- Advances in Plant-Derived Extracellular Vesicles: Implications for Apple-Derived EVs.Plants (Basel, Switzerland) · 2025Review
- Dermatologically Tested Apple-Derived Extracellular Vesicles: Safety, Anti-Aging, and Soothing Benefits for Skin Health.Journal of cosmetic dermatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracellular vesicles (EVs) derived from plant sources, particularly apple-derived vesicles (ADVs), have gained interest for their biocompatibility and bioactive properties in cosmetic, dermatological, and regenerative medicine applications. This study aimed to evaluate the safety and efficacy of a 2% ADV-based formulation, assessing its potential for topical use through a series of standardized in vitro tests. MATERIALS AND
methodsThe ADV-based formulation was subjected to genotoxicity (Ames test), corneal toxicity, skin irritation, corrosion, and sensitization assays, following OECD guidelines. Additionally, its anti-inflammatory and anti-aging effects were assessed through skin redness reduction and wrinkle parameter analysis over 60 days.
resultsADVs exhibited no genotoxic, cytotoxic, corrosive, or sensitizing effects, confirming their safety profile. The formulation significantly reduced skin redness (p < 0.05) and improved wrinkle length, volume, and roughness over time.
conclusionThese findings establish ADVs as safe and effective bioactive ingredients, supporting their potential integration into cosmetic and regenerative applications for skin health and anti-aging treatments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.