Evidence map›Paper›PMID 40685952›Full record

ArticleMolecular nutrition & food research2025

Exploration of Biomarkers of Food Intake in a Caribbean Hispanic Population.

Laurence D Parnell, Liam E Fouhy, Oladimeji Akinlawon, Chao-Qiang Lai, Frederick Nusetor, José M Ordovás, Kelsey M Mangano, Katherine L Tucker, Sabrina E Noel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular nutrition & food research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Laurence D ParnellAgricultural Research Service, US Department of Agriculture, JM-US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA.
Liam E FouhyDepartment of Biomedical and Nutritional Sciences, University of Massachusetts, Lowell, Massachusetts, USA.
Oladimeji AkinlawonAgricultural Research Service, US Department of Agriculture, JM-US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA.
Chao-Qiang LaiAgricultural Research Service, US Department of Agriculture, JM-US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA.
Frederick NusetorBiostatistics and Data Management Unit, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA.
José M OrdovásBiostatistics and Data Management Unit, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA.
Kelsey M ManganoDepartment of Biomedical and Nutritional Sciences, University of Massachusetts, Lowell, Massachusetts, USA.
Katherine L TuckerDepartment of Biomedical and Nutritional Sciences, University of Massachusetts, Lowell, Massachusetts, USA.
Sabrina E NoelDepartment of Biomedical and Nutritional Sciences, University of Massachusetts, Lowell, Massachusetts, USA.

Funding

STATISTICSP50HL105185 · NHLBI · UNIVERSITY OF MASSACHUSETTS LOWELL · PI TUCKER, KATHERINE L · 2010 to 2015
$10.4M
Center for Research/Nutrition &Health among the ElderlyP01AG023394 · NIA · TUFTS UNIVERSITY BOSTON · PI TUCKER, KATHERINE L · 2003 to 2007
$8.1M
Dietary Quality, Cognitive Decline and Brain Health in Puerto Rican AdultsR01AG055948 · NIA · UNIVERSITY OF MASSACHUSETTS LOWELL · PI TUCKER, KATHERINE L · 2017 to 2021
$4.2M
NHLBI NIH HHS P50 HL105185NHLBI NIH HHS P50-HL105185NIA NIH HHS P01 AG023394NIA NIH HHS P01-AG023394NIA NIH HHS R01 AG055948NIA NIH HHS R01- AG055948United States Department of Agriculture
6 · The paper itself

Abstract

Valid measures of dietary intake are essential for health and nutrition research, but typical forms- or interview-based measurements are susceptible to random and systematic errors. Although many biomarkers of food intake (BFIs) have been validated, we aimed to explore how food-BFI relationships are affected by genetic and lifestyle factors among Caribbean Hispanic adults. Dietary, clinical, anthropometric, blood metabolomics, and genotype data from 782 Puerto Rican adults were available. Thirty-one BFI-food intake relationships were assessed using linear regression, including covariates based on significant covariate-BFI associations (i.e., age, body weight, physical activity, and sex). We observed 12 known BFI-food pairs that reached statistical significance, of which 11 remained significant after adjustment. Applying genome-wide association tests of blood metabolites to BFI-food pairs, genetic variants rs7078243 and rs62501664 were identified as modifying relationships with 3-methylxanthine-coffee and 3-methylhistidine-poultry, respectively. Eleven validated biomarker-food intake pairs remained statistically significant after adjusting for covariates. Identification of genotype-BFI associations accentuates that the implementation of certain BFIs will depend on common genetic differences.

Indexed as

BiomarkersEatingHispanic or LatinoAdultAgedCaribbean RegionDietFemaleGenome-Wide Association StudyGenotypeHumansMaleMiddle AgedPolymorphism, Single NucleotidePuerto RicoWhiteBiomarkersbiomarkerdiet assessmentfood intakegeneticsmetabolomics

Identifiers

PMID40685952
PMCPMC12538526

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.