Evidence map›Paper›PMID 40685922›Full record

ArticleThoracic cancer2025

Metagenomic and Metabolomic Profiling Reveals the Impact of High-Fat Diet on Malignant Pleural Effusion.

Qing-Yu Chen, Ming-Ming Shao, Shu-Feng Dong, Huan-Zhong Shi, Feng-Shuang Yi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thoracic cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qing-Yu ChenDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0009-0008-7312-8132
Ming-Ming ShaoDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0009-0005-0225-4447
Shu-Feng DongDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Huan-Zhong ShiDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Feng-Shuang YiDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0003-2822-5618

Funding

Beijing Hospitals Authority Youth Program QML20230303Beijing Scholars Program 048National Natural Science Foundation of China 82200111Natural Science Foundation of Beijing Municipality 7232066Reform and Development Program of Beijing Institute of Respiratory Medicine Ggyfz202314Reform and Development Program of Beijing Institute of Respiratory Medicine Ggyfz202330Reform and Development Program of Beijing Institute of Respiratory Medicine Ggyfz202416
6 · The paper itself

Abstract

backgroundMalignant pleural effusion (MPE) is a common complication in the advanced stage of cancer. High-Fat Diet (HFD)-induced obesity has become a common metabolic background in cancer patients. Recent studies have demonstrated that HFD induces gut dysbiosis, resulting in alterations in metabolites and immune responses. However, its role in MPE remains unclear.

methodsWe established an MPE mouse model under both normal chow and HFD conditions. Metagenomic sequencing of fecal samples and untargeted metabolomics of plasma were performed to assess alterations in gut microbiota and systemic metabolites, respectively. Bioinformatic and statistical analyses were conducted to identify significant microbial taxa and metabolic pathways.

resultsHFD-fed mice exhibited increased pleural effusion. Metagenome data of the intestinal microbiome and metabolome profiles of plasma metabolites revealed key taxa-Akkermansiaceae, Parabacteroides, and Muribaculaceae-as well as significant metabolic pathways involved in sphingolipid metabolism, glycerophospholipid metabolism, and steroid hormone biosynthesis.

conclusionThese findings suggest that HFD may accelerate the MPE progression through modulation of gut microbiota and plasma metabolites, providing new strategies for prevention and treatment.

Indexed as

Diet, High-FatMetabolomeMetabolomicsMetagenomicsPleural Effusion, MalignantAnimalsGastrointestinal MicrobiomeHumansMaleMiceMice, Inbred C57BLhigh‐fat dietmalignant pleural effusionmetabolomicsmetagenomics

Identifiers

PMID40685922
PMCPMC12277645

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.