ReviewFuture medicinal chemistry2025
Exploring norfloxacin analogs in combating antimicrobial resistance: design, mechanistic insights and structure activity relationship.
Review in Future medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Fabrication of Protein Carriers for Intracellular Delivery of Antibiotics Against Intracellular Bacterial Infection.Molecules (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Norfloxacin (NF), a fluoroquinolone (FN) antibiotic, has garnered significant attention for its broad-spectrum antimicrobial activity, particularly against gram-negative bacteria. This review article explores the structural modifications and derivatives of NF that enhance its efficacy and broaden its antimicrobial spectrum. We systematically analyze various chemical modifications, including substitutions at the 7 and 8 positions of the quinolone core, and their impact on antibacterial potency, pharmacokinetics, and resistance profiles. Additionally, we discuss the mechanisms of action of NF derivatives, their effectiveness against resistant strains, and the potential for synergistic combinations with other antimicrobial agents. The review highlights promising candidates from recent studies, emphasizing the need for continued research into NF derivatives as potential therapeutic options in the fight against multidrug-resistant infections. Ultimately, this article aims to provide a comprehensive overview of the advancements in NF derivatives, contributing to the development of novel antimicrobial strategies.
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Registered trials
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