Evidence map›Paper›PMID 40685742›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2025

Bioactive Polysulfate-Based Nano-Assemblies Against Virus Infection.

Guoxin Ma, Mathias Dimde, Kai Ludwig, Latifa Abidal, Julia M Adler, Ricardo Martin Vidal, Benedikt B Kaufer, Jakob Trimpert, Chuanxiong Nie, Rainer Haag

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Bioactive Polysulfate-Based Nano-Assemblies Against Virus Infection.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Guoxin MaInstitute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195, Berlin, Germany.
Mathias DimdeInstitute of Chemistry and Biochemistry, Research Center of Electron Microscopy, Freie Universität Berlin, Fabeckstr 36a, 14195, Berlin, Germany.
Kai LudwigInstitute of Chemistry and Biochemistry, Research Center of Electron Microscopy, Freie Universität Berlin, Fabeckstr 36a, 14195, Berlin, Germany.ORCID 0000-0001-6808-8107
Latifa AbidalInstitute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195, Berlin, Germany.
Julia M AdlerInstitute of Virology, Freie Universität Berlin, Robert von Ostertag-Str. 7, 14163, Berlin, Germany.
Ricardo Martin VidalInstitute of Virology, Freie Universität Berlin, Robert von Ostertag-Str. 7, 14163, Berlin, Germany.ORCID 0000-0002-9670-5640
Benedikt B KauferInstitute of Virology, Freie Universität Berlin, Robert von Ostertag-Str. 7, 14163, Berlin, Germany.ORCID 0000-0003-1328-2695
Jakob TrimpertDepartment of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, 66506, USA.ORCID 0000-0003-1616-0810
Chuanxiong NieInstitute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195, Berlin, Germany.ORCID 0000-0001-7963-1187
Rainer HaagInstitute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195, Berlin, Germany.ORCID 0000-0003-3840-162X

Funding

Deutsche Forschungsgemeinschaft 434130070Deutsche Forschungsgemeinschaft GRK 2662HORIZON EUROPE European Research Council 101055416
6 · The paper itself

Abstract

3D nanosystems equipped with polysulfates as binding sites are effective virus inhibitors due to their ability to dynamically deform while adhering to a virus. Here, a new supramolecular nanosystem assembled from a block copolymer consisting of sulfated linear polyglycerol and polytrimethylene carbonate is presented. It exhibits a unique morphology, 100 nm sized spheres with a distinct brush-like corona. The negatively charged sulfates are distributed on the outer shell and enable exceptional homogeneity of the particles, thereby enhancing the efficiency of multivalent interactions. Various sulfation levels are tested and demonstrated extremely low half-maximal inhibition concentration (IC

Indexed as

Antiviral AgentsNanoparticlesSulfatesAnimalsChlorocebus aethiopsCryoelectron MicroscopyGlycerolHerpesvirus 1, HumanHumansPolymersVero CellsAntiviral AgentsGlycerolpolyglycerolPolymersSulfatesantiviral nanoassemblymultivalent nanosystemspolysulfatesvirus inhibition

Identifiers

PMID40685742
PMCPMC12423918

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.