ArticleNeurodegenerative disease management2025
Multiple sclerosis as a genetic risk factor for Alzheimer's disease: Insights from Mendelian randomisation.
Article in Neurodegenerative disease management, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Is there a link between multiple sclerosis and Alzheimer disease? A critical note.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- The complexity of dementia development and its comorbidities: The collaborative cross-mouse population for multivarious tasks approach.Animal models and experimental medicine · 2026Review
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Authors and funding
4 authors.
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Abstract
backgroundInflammation is implicated in neurodegeneration, but the causal link between multiple sclerosis and Alzheimer's disease remains unclear.
objectiveTo investigate the genetic relationship between MS and AD using Mendelian Randomization and assess downstream molecular effects.
methodsTwo-sample MR was conducted using GWAS summary statistics, with IVW and MR Egger methods. Sensitivity analyses assessed pleiotropy and heterogeneity. eQTL and KEGG pathway analyses explored gene expression and functional relevance.
resultsSixty-four SNPs from European MS GWAS were selected for MR analysis; an African American dataset showed no significant SNPs. IVW and MR-Egger indicated a positive causal association between MS and AD (
conclusionMS may increase AD risk via shared T-cell - mediated immunogenetic mechanisms.
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