Trial reportBrain and behavior2025
The Evaluation of Memantine Effect on Tinnitus Severity.
Trial report in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Application of neurodegenerative disease treatment strategies in tinnitus: mechanisms, translation, and prospects.Frontiers in aging neuroscience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
purposeTinnitus is a common condition where a person perceives sound despite there being no external auditory stimuli. It is proven that overexpression of NMDA (N-methyl-d-aspartate) glutamate receptors increases the sensitivity of neurons to glutamate transmission, creating a destructive cycle of excitotoxicity. NMDA receptor antagonists, such as memantine, seem to be effective in treating tinnitus. This study aimed to examine the effectiveness of memantine as a treatment for tinnitus in a double-blind randomized placebo control clinical trial.
methodsThe participants were patients with tinnitus. A total of 70 patients were randomly assigned into two groups, intervention and a placebo, with an equal number of patients in each group. Both groups received conventional treatment with cinnarizine at a dose of 25 mg twice a day. In the intervention group, memantine was added to cinnarizine with starting dose of 5 mg. Tinnitus Severity Index (TSI) and Numeric Rating Scale (NRS) were recorded before and after study in both groups.
findingsThere was no significant difference in the initial mean of NRS and TSI scores between two groups. After treatment, the mean NRS and TSI scores were significantly lower in the intervention group. Although the changes in mean NRS scores were significant in both groups at the end of study but only the mean TSI scores were significantly decreased in the intervention group.
conclusionOn the basis of these findings, it is suggested that memantine may have remarkable effect in reducing tinnitus and its discomfort.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.