Evidence map›Paper›PMID 40685683›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

A Mesoporous Calcium Peroxide Nanocuboid with High Tumor Accumulation Across Biological Barriers for High Efficacy Tumor Therapy.

Qingdeng Fan, Min Wang, Jie Lin, Ya Huang, Jing Yang, Jiaoyang Zhu, Bin Ren, Li Sun, Zongheng Li, Aochi Liu and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Qingdeng FanSchool of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Baiyun, Guangzhou, Guangdong, 510515, P. R. China.
Min WangMedical Imaging Center, Nanfang Hospital, Southern Medical University, 1023 Shatai South Road, Baiyun, Guangzhou, Guangdong, 510515, P. R. China.
Jie LinNingbo Institute of Materials Technology and Engineering, CAS, 1219 Zhongguan West Road, Ningbo, 315201, P. R. China.
Ya HuangSchool of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Baiyun, Guangzhou, Guangdong, 510515, P. R. China.
Jing YangSchool of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Baiyun, Guangzhou, Guangdong, 510515, P. R. China.
Jiaoyang ZhuSchool of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Baiyun, Guangzhou, Guangdong, 510515, P. R. China.
Bin RenSchool of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Baiyun, Guangzhou, Guangdong, 510515, P. R. China.
Li SunNingbo Institute of Materials Technology and Engineering, CAS, 1219 Zhongguan West Road, Ningbo, 315201, P. R. China.
Zongheng LiSchool of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Baiyun, Guangzhou, Guangdong, 510515, P. R. China.
Aochi LiuNingbo Institute of Materials Technology and Engineering, CAS, 1219 Zhongguan West Road, Ningbo, 315201, P. R. China.
Wei XiongMedical Imaging Center, Nanfang Hospital, Southern Medical University, 1023 Shatai South Road, Baiyun, Guangzhou, Guangdong, 510515, P. R. China.
Zhenni WeiDepartments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Clinical Imaging Research Centre, Nanomedicine Translational Research Program, Yong Loo Lin School of Medicine and College of Design and Engineering, National University of Singapore, Singapore, 119228, Singapore.
Lin HuangSchool of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Baiyun, Guangzhou, Guangdong, 510515, P. R. China.
Chenggong YanMedical Imaging Center, Nanfang Hospital, Southern Medical University, 1023 Shatai South Road, Baiyun, Guangzhou, Guangdong, 510515, P. R. China.
Ge WenMedical Imaging Center, Nanfang Hospital, Southern Medical University, 1023 Shatai South Road, Baiyun, Guangzhou, Guangdong, 510515, P. R. China.
Zhao ChenMedical Imaging Center, Nanfang Hospital, Southern Medical University, 1023 Shatai South Road, Baiyun, Guangzhou, Guangdong, 510515, P. R. China.
Xiaoyuan ChenDepartments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Clinical Imaging Research Centre, Nanomedicine Translational Research Program, Yong Loo Lin School of Medicine and College of Design and Engineering, National University of Singapore, Singapore, 119228, Singapore.ORCID https://orcid.org/0000-0002-9622-0870
Zheyu ShenSchool of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Baiyun, Guangzhou, Guangdong, 510515, P. R. China.

Funding

Guangdong Provincial Natural Science Foundation of China 2024A1515012639National Natural Science Foundation of China 32271374Suzhou Zheci Pharmaceutical Technology Co., LTD K924309507
6 · The paper itself

Abstract

The common problem of tumor therapy based on nanoparticles is the limited efficacy due to the blockage of tumor accumulation by biological barriers. To enhance the drug delivery of nanoparticles across biological barriers and augment their tumor accumulation, herein, a mesoporous calcium peroxide nanocuboid (MCPNC) is developed via a facile hydrolysis-precipitation method, which can be utilized for high efficacy tumor therapy by promoting a positive feedback loop of Fenton reaction. The biodistribution results demonstrate that MCPNC exhibits higher accumulation in various tissues than calcium peroxide nanosphere (CPNS). Ferroheme (FH) and exceedingly small magnetic iron oxide nanoparticle (IO) loaded MCPNC is modified with hyaluronic acid (HA), forming MCPNC-FH-IO@HA. Under acidic tumor microenvironment (TME), Fe

Indexed as

NanoparticlesNeoplasmsPeroxidesAnimalsCell Line, TumorDrug Delivery SystemsHumansMiceMice, Inbred BALB CPorosityReactive Oxygen SpeciesTissue DistributionTumor Microenvironmentcalcium peroxidePeroxidesReactive Oxygen Speciesenhanced drug delivery across biological barriersmagnetic resonance imaging (MRI)mesoporous calcium peroxide nanocuboid (MCPNC)positive feedback loop of Fenton reactiontargeted therapy for tumors

Identifiers

PMID40685683
PMCPMC12533144

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.