Evidence map›Paper›PMID 40685618›Full record

ArticleGut microbes2025

Blood-borne immune cells carry low biomass DNA remnants of microbes in patients with colorectal cancer or inflammatory bowel disease.

Yasser Morsy, Åsa Walberg, Paulina Wawrzyniak, Barbara Hubeli, Luca Truscello, Celine Mamie, Ania Niechcial, Emilie Gueguen, Roberto Manzini, Claudia Gottier and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Yasser MorsyDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-8234-1877
Åsa WalbergDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Paulina WawrzyniakDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Barbara HubeliDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Luca TruscelloDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Celine MamieDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Ania NiechcialDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Emilie GueguenDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Roberto ManziniDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Claudia GottierDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Silvia LangDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Sylvie ScharlDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Sena BlümelDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Luc BiedermannDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Gerhard RoglerDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Matthias TurinaDepartment of Visceral and Transplant Surgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Michaela RamserDepartment of Visceral and Transplant Surgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Henrik PetrowskyDepartment of Visceral and Transplant Surgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Isabelle C ArnoldInstitute of Experimental Immunology, University of Zürich, Zurich, Switzerland.
Sebastian ZeissigCenter for Regenerative Therapies Dresden (CRTD), Technische Universität (TU) Dresden, and Department of Medicine I, University Medical Center Dresden, Dresden, Germany.
Nicola ZamboniInstitute of Molecular Systems Biology, Federal Institute of Technology Zurich, Zurich, Switzerland.
Adrian EgliInstitute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
Jan Hendrik NiessDepartment of Gastroenterology and Hepatology, University Digestive Healthcare Center, Basel, Switzerland.
Petr HruzDepartment of Gastroenterology and Hepatology, University Digestive Healthcare Center, Basel, Switzerland.
Alexander KnuthDepartment of Medical Oncology and Hematology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Ralph FritschDepartment of Medical Oncology and Hematology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Markus G ManzDepartment of Medical Oncology and Hematology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Marcin WawrzyniakDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Michael ScharlDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-6729-1469

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The involvement of the intestinal microbiome in the pathogenesis of inflammatory bowel disease (IBD) and colorectal cancer (CRC), is well-established. Bacteria interact with immune cells at sites of intestinal inflammation, but also in the CRC tumor microenvironment. We hypothesized that bacterial remnants translocate within peripheral blood mononuclear cells (PBMCs) into the circulation and thus explored the composition of the detectable microbiome in PBMCs of patients with CRC or IBD compared to healthy controls. The PBMC microbiome profiles partially align with the tumor-derived or intestinal tissue-derived microbiome signatures obtained from the same patients with CRC or IBD, respectively. Our metagenomics data, supported by 16S-rRNA-FISH-Flow, imaging flow cytometry and species-specific qPCR, revealed the presence of translocated bacterial genetic sequences in the patients with CRC and IBD. Thus, our data suggest that in patients with intestinal barrier leakage, there is the potential for the translocation of bacterial remnants into the circulation via PBMCs.

Indexed as

BacteriaColorectal NeoplasmsDNA, BacterialGastrointestinal MicrobiomeInflammatory Bowel DiseasesLeukocytes, MononuclearAdultAgedBacterial TranslocationFemaleHumansMaleMetagenomicsMiddle AgedRNA, Ribosomal, 16SDNA, BacterialRNA, Ribosomal, 16Scancer and microbiomecolorectal cancer metastasisinflammatory bowel disease pathogenesisintestinal epithelial barrier defectMicrobiomemicrobiome host interactionperipheral blood mononuclear cells

Identifiers

PMID40685618
PMCPMC12283013

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.