Evidence map›Paper›PMID 40685567›Full record

ArticleRenal failure2025

METTL3 alleviates renal tubular mitochondrial dysfunction by regulating the TUG1/PGC-1a axis in an IGF2BP2-dependent manner in diabetic nephropathy.

Tong Chen, Juan Wang, Yanyan Xu, Yonghong Zhu, Ying Jin, Qiuling Fan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tong ChenDepartment of Nephrology, Shenyang Seventh People's Hospital, Shenyang, Liaoning, China.
Juan WangDepartment of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yanyan XuDepartment of Nephrology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Yonghong ZhuDepartment of Nephrology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Ying JinDepartment of Acupuncture, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China.
Qiuling FanDepartment of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo explore the N6-methyladenosine (m

methods

resultsMETTL3 and TUG1 expression levels decreased in the kidneys of diabetic mice and HG-treated HK-2 cells. Mechanistically, METTL3-mediated m

conclusionMETTL3 targets TUG1/PGC-1α and ameliorates mitochondrial dysfunction in diabetic nephropathy in an IGF2BP2-dependent manner.

Indexed as

Diabetic NephropathiesKidney TubulesMethyltransferasesMitochondriaPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaRNA-Binding ProteinsRNA, Long NoncodingAdenosineAnimalsApoptosisCell LineDisease Models, AnimalGlucoseHumansMaleMiceAdenosineGlucoseIGF2BP2 protein, humanIGF2BP2 protein, mouselong non-coding RNA TUG1, mouseMethyltransferasesMETTL3 protein, humanMettl3 protein, mouseN-methyladenosinePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseReactive Oxygen SpeciesRNA-Binding ProteinsRNA, Long NoncodingDiabetic nephropathylncRNA TUG1m6A modificationMETTL3mitochondria

Identifiers

PMID40685567
PMCPMC12281650

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.