Evidence map›Paper›PMID 40685446›Full record

ArticleScientific reports2025

An in vivo rat model for comparing selective blockade between sensory and motor nerve conduction.

Yi Teng, Xian Zou, Jin Liu, Xiangyu Hu, Cheng Zhou, Mengchan Ou

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yi Teng *Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, China.
Xian Zou *Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, China.
Jin LiuDepartment of Anesthesiology, West China Hospital of Sichuan University, Chengdu, China.
Xiangyu HuDepartment of Anesthesiology, West China Hospital of Sichuan University, Chengdu, China.
Cheng ZhouResearch Center of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.
Mengchan OuDepartment of Anesthesiology, West China Hospital of Sichuan University, Chengdu, China. mengchanou@wchscu.edu.cn.

Funding

National Natural Science Foundation of China 82271290National Natural Science Foundation of China 82371280Science and Technology Department of Sichuan Province, China 2023NSFSC1565Science and Technology Department of Sichuan Province, China 2023ZYD0168
6 · The paper itself

Abstract

Sensory-selective nerve blockade is highly useful for pain management in clinical practice, but developing such blockers remains challenging. A major handicap is the lack of objective in vivo animal models to evaluate motor and sensory nerve conduction simultaneously. Due to anatomical structures, motor evoked potentials (MEPs) and/or somatosensory evoked potentials (SSEPs) may be used to assess nerve conduction. MEPs were elicited by stimulating motor cortex and recorded from contralateral hind limb. SSEPs were generated by stimulating sciatic nerve and recorded from contralateral sensory cortex. Amplitude/latency changes were recorded under various physiological conditions (e.g., anesthesia, durations, temperatures, and oxygen) and drug interventions for validation. Compared to sevoflurane, propofol minimally inhibited MEPs at sedative doses and was therefore used during recordings. Both hypothermia (34-36 °C) and hyperthermia (38-40 °C) significantly suppressed MEP and SSEP amplitudes (P < 0.0001). Reduced oxygen saturation (SaO

Indexed as

Evoked Potentials, MotorMotor NeuronsNerve BlockNeural ConductionAnimalsEvoked Potentials, SomatosensoryLidocaineMaleModels, AnimalPropofolRatsRats, Sprague-DawleySciatic NerveSevofluraneLidocainePropofolSevofluraneEvoked potentialsIn vivo animal modelLocal anestheticsSelective nerve blockadeSensory-motor separation

Identifiers

PMID40685446
PMCPMC12277404

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.