Evidence map›Paper›PMID 40685385›Full record

ArticleScientific reports2025

Ciprofol suppresses glycolysis and EMT in colorectal cancer cells by activating APC to modulate the Wnt/β-catenin signaling pathway.

Han Wu, Jiening Gao, Yong Wang, Yao Zhang, Li Jia, Weijing Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Han WuAnesthesiology Department, The Fourth Hospital of Hebei Medical University, No.169 Tianshan Street, Shijiazhuang, 050011, Hebei Province, China.
Jiening GaoAnesthesiology Department, The Fourth Hospital of Hebei Medical University, No.169 Tianshan Street, Shijiazhuang, 050011, Hebei Province, China.
Yong WangAnesthesiology Department, The Fourth Hospital of Hebei Medical University, No.169 Tianshan Street, Shijiazhuang, 050011, Hebei Province, China.
Yao ZhangBaoding Maternal and Child Health Hospital, Baoding, 071000, China.
Li JiaAnesthesiology Department, The Fourth Hospital of Hebei Medical University, No.169 Tianshan Street, Shijiazhuang, 050011, Hebei Province, China. jiali070825@163.com.
Weijing LiAnesthesiology Department, The Fourth Hospital of Hebei Medical University, No.169 Tianshan Street, Shijiazhuang, 050011, Hebei Province, China. liweijinghbyd@hebmu.edu.cn.

Funding

Precision Medicine Joint Fund Cultivation Project of Hebei Province Special Natural Science Foundation for Basic Research H2020206397
6 · The paper itself

Abstract

Ciprofol, an innovative anesthetic derived from propofol, has not yet been studied in detail regarding its effects in colorectal cancer (CRC). This study mainly explored the effects of Ciprofol on the epithelial-mesenchymal transition (EMT) process, glycolysis, and the Wnt/β-catenin signaling pathway in CRC cells. Through in vitro and in vivo experiments, we successfully demonstrated that Ciprofol can inhibit the proliferative capacity of CRC cells and tissues. It can also suppress the invasion, metastasis, and EMT process of CRC cells. In addition, treatment with Ciprofol decreased the oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) in CRC cells, thereby inhibiting cellular glycolysis. However, knockdown of APC could reverse the effects of Ciprofol. Regarding the mechanism, overexpression of APC was able to activate the Wnt/β-catenin signaling pathway. Ciprofol could activate the expression of APC, subsequently activating the Wnt/β-catenin signaling pathway. The addition of Derivative83 could reverse Ciprofol - mediated regulation of this pathway. This study still has certain limitations. For example, the verification through clinical trials, as well as issues such as the safety and efficacy of ciprofol, remain the key focuses of future research.

Indexed as

Adenomatous Polyposis Coli ProteinColorectal NeoplasmsEpithelial-Mesenchymal TransitionGlycolysisWnt Signaling PathwayAnimalsbeta CateninCell Line, TumorCell ProliferationCyclopropanesGene Expression Regulation, NeoplasticHumansMiceMice, NudeXenograft Model Antitumor Assays(2-(1R)-1-cyclopropyl)ethyl-6-isopropyl-phenolAdenomatous Polyposis Coli ProteinAPC protein, humanbeta CateninCyclopropanesAdenomatous polyposis coliCiprofolEpithelial-mesenchymal transitionGlycolysisWnt/β-catenin signaling pathway

Identifiers

PMID40685385
PMCPMC12277440

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.