Blood speckle tracking to predict functional status in pediatric patients with dilated cardiomyopathy.

Antoine Fakhry AbdelMassih, Soha Emam, Aliaa Ibrahim Mabrouk, Manal AbdelHameed

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Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Antoine Fakhry AbdelMassihDepartment of Pediatrics, Pediatric Cardiology Division, Faculty of Medicine, Specialized Pediatric Hospital, Cairo University, Cairo University Children Hospital, Kasr Al Ainy Street, Cairo, 12411, Egypt. antoine.abdelmassih@kasralainy.edu.eg.

Soha EmamDepartment of Pediatrics, Pediatric Cardiology Division, Faculty of Medicine, Specialized Pediatric Hospital, Cairo University, Cairo University Children Hospital, Kasr Al Ainy Street, Cairo, 12411, Egypt.

Aliaa Ibrahim MabroukPediatrics' Master of Science training program, Faculty of Medicine, Cairo University Children Hospital, Cairo University, Cairo, Egypt.

Manal AbdelHameedDepartment of Pediatrics, Pediatric Cardiology Division, Faculty of Medicine, Specialized Pediatric Hospital, Cairo University, Cairo University Children Hospital, Kasr Al Ainy Street, Cairo, 12411, Egypt.

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6 · The paper itself

Abstract

backgroundDilated Cardiomyopathy (DCM) is an important cause of significant cardiac functional impairment in pediatric patients. There is to date debate on which echocardiographic variable correlates better with the functional status of the patient. METHODOLOGY: 28 DCM patients (NYHA class II and III), and 30 controls were enrolled in the study, where advanced echocardiographic examination was used to assess LV (Left ventricular) function. Tissue Doppler, 2D speckle tracking for PSI (post-systolic strain index calculation), and blood speckle tracking for the timing of LV vortex formation were implemented.

resultsIntriguingly, none of LV GLS and GAS (Global longitudinal and area strain), or EF (Ejection fraction, were able to differentiate NYHA II and III subgroups of cases. In contrast, PSI, and systolic vortex formation were significantly different between subgroups of cases; systolic vortex was seen in 33% of NYHA II patients compared to 77% of NYHA III patients, a PSI median value of 5% was seen in NYHA III cases, and a cut-off >4% was 92% sensitive in predicting worse manifestations.

conclusionDyssynchrony; seems to play a significant role in orchestrating symptoms of heart failure. In this context, blood speckle tracking study seems a promising bedside method, in its assessment. A large room for improvement and systemization of its assessment is still needed to objectivize its use.

Indexed as

Cardiomyopathy, DilatedEchocardiography, DopplerVentricular Dysfunction, LeftVentricular Function, LeftAdolescentAge FactorsCase-Control StudiesChildChild, PreschoolFemaleFunctional StatusHumansMalePredictive Value of TestsPrognosisReproducibility of ResultsDCMDyssynchronyNYHAPost-systolic indexVortex timing

Identifiers

PMID40685374

DOI10.1186/s12872-025-04984-2

PMCPMC12278534

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.