Evidence map›Paper›PMID 40685365›Full record

ArticleJournal of nanobiotechnology2025

Multifunctional nanoagent for enhanced cancer radioimmunotherapy via pyroptosis and cGAS-STING activation.

Ziting Xu, Yang Gao, Li Zhang, Yingshan Gao, Yushu Liao, Yu Liang, Zhen Yuan, Yingjia Li, Bingxia Zhao, Ge Wen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ziting Xu *Department of Medical Imaging, Department of Ultrasound, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Yang Gao *Department of Medical Imaging, Department of Ultrasound, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Li Zhang *Department of Medical Imaging, Department of Ultrasound, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Yingshan GaoDepartment of Medical Imaging, Department of Ultrasound, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Yushu LiaoCancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Yu LiangDepartment of Medical Imaging, Department of Ultrasound, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Zhen YuanFaculty of Health Sciences, University of Macau, Macau, 999078, China.
Yingjia LiDepartment of Medical Imaging, Department of Ultrasound, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. lyjia@smu.edu.cn.
Bingxia ZhaoCancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China. bingxiaz@foxmail.com.
Ge WenDepartment of Medical Imaging, Department of Ultrasound, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. m13360022166@163.com.

Funding

China Postdoctoral Science Foundation 2023M731552Guangzhou Municipal Science and Technology Project 2023B03J1350National College Students Innovation and Entrepreneurship Training Program S202412121145National Natural Science Foundation of China 82072056National Natural Science Foundation of China 82102081National Natural Science Foundation of China 82202155National Natural Science Foundation of China 82271998
6 · The paper itself

Abstract

The immunosuppressive tumor microenvironment (ITME) and inherent radioresistance of tumor cells limit the effectiveness of radioimmunotherapy and exacerbate immune evasion. To address these challenges, PEGylated Azacitidine-loaded and Mn

Indexed as

Membrane ProteinsNanoparticlesNeoplasmsNucleotidyltransferasesPyroptosisRadioimmunotherapyAnimalsCell Line, TumorCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseHumansManganeseMiceRadiation-Sensitizing AgentsReactive Oxygen SpeciesSTING ProteinTumor MicroenvironmentcGAS protein, humanCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseManganeseMembrane ProteinsNucleotidyltransferasesRadiation-Sensitizing AgentsReactive Oxygen SpeciesSTING1 protein, humanSTING ProteinCa overloadcGAS-STING pathwayPyroptosisRadioimmunotherapyRadiosensitization

Identifiers

PMID40685365
PMCPMC12278542

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.