ArticleClinical and experimental pediatrics2025
Liposomal SunActive versus conventional iron for treatment of iron-deficiency anemia in children aged 2-12 years: a prospective randomized controlled trial.
Article in Clinical and experimental pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Safety and efficacy of liposomal iron for iron deficiency anemia in pediatric population: A systematic review and meta-analysis of randomized controlled trials.European journal of pediatrics · 2026Pooled it
- Oral liposomal iron vs. oral iron polymaltose in children with chronic kidney disease iron deficiency anemia: a cross-over study.Pediatric nephrology (Berlin, Germany) · 2026Trial
- Iron Deficiency in Endocrine Diseases and the Therapeutic Role of Liposomal Iron: A Comprehensive Review.Biomedicines · 2026Review
- Pediatric Oral Iron Therapy: Choosing the Right Product for Your Patient.Hematology reports · 2026Review
- Thrombosis and Anemia in Pediatric Inflammatory Bowel Disease: Pathophysiology, Clinical Impact and Future Directions.International journal of molecular sciences · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
backgroundLiposomal iron, a novel oral formulation of ferric pyrophosphate that demonstrates improved gastrointestinal absorption and bioavailability with fewer side effects than conventional iron, represents a significant advancement in the treatment of iron-deficiency anemia (IDA). PURPOSE: To conduct an in-depth comparative study of liposomal SunActive and conventional iron supplements (iron polymaltose complex) for treating IDA in children aged 2-12 years.
methodsThis prospective randomized controlled trial included 192 children who visited the outpatient clinic of the Pediatric Department at Menoufia University Hospital and were diagnosed with IDA. The patients were divided into group 1, 96 pediatric patients receiving oral liposomal SunActive iron; and group 2, 96 pediatric patients treated with conventional oral iron (iron polymaltose complex).
resultsAfter 1 month of oral iron therapy, group 1 exhibited higher hemoglobin, hematocrit, serum ferritin, and serum iron levels and greater transferrin saturation than group 2. After 6 months of oral iron therapy, hemoglobin level (P<0.001), iron profile (P<0.001), and growth-related anthropometric measurements were higher in group 1 versus group 2 (P<0.001for z score for weight).
conclusionIron supplements effectively improve anthropometric measurements, complete blood count parameters, and iron profiles. However, orally administered liposomal SunActive iron exhibits better effects, reduced drug refusal rates, and improved compliance rates, thereby benefiting children's growth.
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