Evidence map›Paper›PMID 40685228›Full record

ArticleLupus science & medicine2025

Higher PM2.5 exposure increases the risk of incident systemic lupus erythematosus: a prospective cohort study in Taiwan.

Yun-Ju Lai, Li-Jung Chen, Yu-Kai Lin, Su-Fen Wang, Mei-Ju Chen, Jason Jiunshiou Lee, Chu-Chieh Chen, Yi-Tui Chen, Ping-Yen Chung, Li-Fei Hsu and 6 more

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In one paragraph

Article in Lupus science & medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yun-Ju Lai *National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
Li-Jung ChenDepartment of Exercise Health Science, National Taiwan University of Sport, Taichung, Taiwan.
Yu-Kai Lin *Department of Health and Welfare, College of City Management University of Taipei, Taipei, Taiwan.
Su-Fen WangDepartment of Geography, National Changhua University of Education, Changhua, Taiwan.
Mei-Ju Chen *Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
Jason Jiunshiou Lee *Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
Chu-Chieh ChenDepartment of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
Yi-Tui ChenDepartment of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
Ping-Yen ChungEmergency Department, Taipei City Hospital Heping Branch, Taipei, Taiwan.
Li-Fei HsuTaipei City Hospital Heping Branch, Taipei, Taiwan.
Kuei-Zuo LaiInstitute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.
Matthew N AhmadiUniversity of Sydney, Sydney, New South Wales, Australia.
Elif Inan-ErogluUniversity of Sydney, Sydney, New South Wales, Australia.
Nicholas A KoemelUniversity of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-5463-6894
Yung-Feng Yen *National Yang Ming Chiao Tung University, Hsinchu, Taiwan yfyen1@gmail.com.ORCID 0000-0002-4469-4732
Po-Wen KuNational Chung Hsing University, Taichung, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe interaction between fine particulate matter (PM2.5) and genetic factors can lead to epigenetic modifications, potentially increasing the risk of SLE development. However, the impact of PM2.5 on incident SLE development remains unelucidated. This study investigated the effects of year-to-year variations in PM2.5 exposure on incident SLE risk in Taiwanese adults.

methodsIn this longitudinal study, we followed up 268 254 adults from the Taiwan MJ cohort (2005-2017) for 9.8 years to identify incident SLE cases, ascertained from patients' clinical and laboratory reports. Residential address-specific annual PM2.5 concentrations were obtained from Taiwan Air Quality-Monitoring sites. We employed a time-dependent Cox regression model, considering death as a competing risk, to assess the impact of year-to-year variations of PM2.5 exposure on SLE development.

resultsDuring 2 628 889 person-years of follow-up, 151 (0.1%) individuals developed new-onset SLE. Participants with higher levels of PM2.5 exposure (per 5 μg/m

conclusionPM2.5 exposure emerged as a risk factor for incident SLE. Air pollution mitigation strategies should be considered as a preventive measure for SLE.

Indexed as

Air PollutantsAir PollutionEnvironmental ExposureLupus Erythematosus, SystemicParticulate MatterAdultFemaleHumansIncidenceLongitudinal StudiesMaleMiddle AgedProportional Hazards ModelsProspective StudiesRisk FactorsTaiwanAir PollutantsParticulate MatterEpidemiologyRisk FactorsSystemic Lupus Erythematosus

Identifiers

PMID40685228
PMCPMC12278130

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.