Evidence map›Paper›PMID 40684769›Full record

ArticleHormone research in paediatrics2025

A Growth Prediction Model from Mid-Puberty to Near Adult Height in Adolescents with Idiopathic Isolated Growth Hormone Deficiency Treated with Growth Hormone.

Joeri Vliegenthart, Maria A J de Ridder, Jan Maarten Wit, Ardine M J Reedijk, Raoul D Oude Engberink, Erica L T van den Akker, Danielle C M van der Kaay, SEENEZ Growth Hormone Consortium

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Article in Hormone research in paediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Joeri VliegenthartDivision of Pediatric Endocrinology, Department of Pediatrics, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands.
Maria A J de RidderDepartment of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.
Jan Maarten WitDivision of Pediatric Endocrinology, Department of Pediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands.
Ardine M J ReedijkDutch Growth Research Foundation, Rotterdam, The Netherlands.
Raoul D Oude EngberinkDepartment of Clinical Chemistry, HagaZiekenhuis, The Hague, The Netherlands.
Erica L T van den AkkerDivision of Pediatric Endocrinology, Department of Pediatrics, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands.
Danielle C M van der KaayDivision of Pediatric Endocrinology, Department of Pediatrics, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands.
SEENEZ Growth Hormone Consortium

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRecombinant human growth hormone (rhGH) treatment of children with idiopathic isolated growth hormone deficiency (IIGHD) typically results in catch-up growth for several years followed by a period of normal growth. The effect of rhGH treatment on late pubertal height gain in adolescents with IIGHD has remained unclear. This study aimed to develop and validate a prediction model for height gain from mid-puberty to near adult height (NAH) in patients with IIGHD, treated with rhGH.

methodsData from the Dutch National Registry of Growth Hormone Treatment in Children were used, focusing on 151 patients who received rhGH treatment until NAH. Predictors included age, bone age, Tanner stage, and target height SDS minus height SDS at mid-puberty. Validation was performed in 33 males and 7 females who had a normal GH response in a GH stimulation test at mid-puberty and continued rhGH until NAH.

resultsThe model explained 48% of the variance for males (residual SD 4.16 cm) and 18% for females (residual SD 3.64 cm). Validation showed a mean (SD) difference of 1.48 (2.36) cm for males and 3.57 (2.66) cm for females between predicted and attained NAH.

conclusionFor females, explained variance was insufficient to reliably predict height gain. For GH sufficient males, the model can be used to assess efficacy of continuing or discontinuing rhGH treatment at mid-puberty in future studies.

Indexed as

Growth hormoneIdiopathic isolated growth hormone deficiencyMid-pubertyNear adult heightPrediction model

Identifiers

PMID40684769
PMCPMC12503576

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