Evidence map›Paper›PMID 40684522›Full record

Trial reportDrug and alcohol dependence2025

Effects of the Communities That HEAL intervention on initiation, retention, and linkage to medications for opioid use disorder (MOUD): A cluster randomized wait-list controlled trial.

Jennifer L Brown, Marc R Larochelle, Laura C Fanucchi, Deirdre C Calvert, Aimee N C Campbell, Redonna K Chandler, Daniel J Feaster, LaShawn M Glasgow, Erin B Gibson, JaNae Holloway and 59 more

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug and alcohol dependence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04111939 (HEALing Communities Study), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04111939 nacompletednot on this map

HEALing Communities Study: Developing and Testing an Integrated Approach to Address the Opioid Crisis

TypeinterventionalSponsorRTI InternationalRan2019 to 2025Enrolled67ConditionsOpioid Use Disorder (OUD)ArmsCommunities That HEAL, Wait-list control
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

69 authors.

Jennifer L BrownDepartment of Psychological Sciences, Purdue University, West Lafayette, IN, USA. Electronic address: jenniferbrown@purdue.edu.
Marc R LarochelleSection of General Internal Medicine, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine and Boston Medical Center, Boston, MA, USA.
Laura C FanucchiDepartment of Medicine, Center on Drug and Alcohol Research, University of Kentucky, Lexington, KY, USA.
Deirdre C CalvertMDPH, Bureau of Substance Addiction Services, Boston, MA, USA.
Aimee N C CampbellDepartment of Psychiatry, Columbia University Irving Medical Center, New York, NY USA.
Redonna K ChandlerNational Institute on Drug Abuse, Bethesda, MD, USA.
Daniel J FeasterUniversity of Miami, Miami, FL, USA.
LaShawn M GlasgowRTI International, Research Triangle Park, NC, USA.
Erin B GibsonClinical Addiction Research and Education Unit, Section of General Internal Medicine, Department of Medicine, Boston Medical Center, Boston, MA, USA.
JaNae HollowayRTI International, Research Triangle Park, NC, USA.
Michelle R LofwallDepartment of Behavioral Science, Center on Drug and Alcohol Research, University of Kentucky, Lexington, KY, USA.
Aimee MackGovernment Resource Center, Ohio Colleges of Medicine, Ohio State University, Columbus, OH, USA.
Nicole MackRTI International, Research Triangle Park, NC, USA.
Edward V NunesDepartment of Psychiatry, Columbia University Irving Medical Center, New York, NY USA.
Jeffery C TalbertDepartment of Medicine, Center on Drug and Alcohol Research, University of Kentucky, Lexington, KY, USA; Division of Biomedical Informatics, College of Medicine, University of Kentucky, Lexington, KY, USA.
Sylvia TanRTI International, Research Triangle Park, NC, USA.
Nathan VandergriftRTI International, Research Triangle Park, NC, USA.
Jennifer VillaniNational Institute on Drug Abuse, Bethesda, MD, USA.
Kat AsmanRTI International, Research Triangle Park, NC, USA.
Hermik Babakhanlou-ChaseMDPH, Bureau of Substance Addiction Services, Boston, MA, USA.
Sarah M BagleyDepartments of Medicine and Pediatrics, Chobanian & Avedisian School of Medicine, Boston Medical Center, Boston, MA, USA.
Tracy A BattagliaDepartments of Medicine and Pediatrics, Chobanian & Avedisian School of Medicine, Boston Medical Center, Boston, MA, USA.
Derek BlevinsDepartment of Psychiatry, Columbia University Irving Medical Center, New York, NY USA.
Carly BriddenBoston Medical Center, Boston, MA, USA.
Debbie M ChengBoston University School of Public Health/Department of Biostatistics, Boston, MA, USA.
Mia ChristopherRTI International, Research Triangle Park, NC, USA.
Lindsay W CoganNew York State Department of Health-Office of Health Services Quality and Analytics, New York, NY, USA.
Chinazo O CunninghamNew York State Office of Addiction Services and Supports, Albany, NY, USA.
Barry EgglestonRTI International, Research Triangle Park, NC, USA.
Naleef FareedCollege of Medicine, The Ohio State University, Columbus, OH, USA.
Soledad FernandezCollege of Medicine, The Ohio State University, Columbus, OH, USA.
Darcy A FreedmanCase Western Reserve University School of Medicine, Department of Population and Quantitative Health Sciences, Cleveland, OH, USA.
Caroline E FreiermuthUniversity of Cincinnati, College of Medicine, Department of Emergency Medicine, Cincinnati, OH, USA.
Bridget FreisthlerThe Ohio State University, College of Social Work, Columbus, OH, USA.
Louisa GilbertColumbia University, Social Intervention Group, School of Social Work, New York, NY, USA.
Lindsey HammerslagDivision of Biomedical Informatics, College of Medicine, University of Kentucky, Lexington, KY, USA.
Daniel HarrisUniversity of Kentucky College of Pharmacy, Department of Pharmacy Practice and Science, Lexington, KY, USA.
Timothy HuntColumbia University, Social Intervention Group, School of Social Work, New York, NY, USA.
Shazia HussainNew York State Office of Addiction Services and Supports, Albany, NY, USA.
Phuong HuynhCollege of Medicine, The Ohio State University, Columbus, OH, USA.
Rebecca D JacksonCollege of Medicine, The Ohio State University, Columbus, OH, USA.
Emily B KauffmanCollege of Medicine, The Ohio State University, Columbus, OH, USA.
Charles KnottRTI International, Research Triangle Park, NC, USA.
Hannah K KnudsenDepartment of Behavioral Science, Center on Drug and Alcohol Research, University of Kentucky, Lexington, KY, USA.
R Craig LefebvreRTI International, Research Triangle Park, NC, USA.
Frances R LevinDepartment of Psychiatry, Columbia University Irving Medical Center, New York, NY USA.
Rick MassattiOhio Department of Mental Health & Addiction Services, Columbus, OH, USA.
Ann Scheck McAlearneyCollege of Medicine, The Ohio State University, Columbus, OH, USA.
Jake R MorganDepartment of Health Law, Policy & Management, Boston University School of Public Health, Boston, MA, USA.
Rosie Munoz LopezDepartments of Medicine and Pediatrics, Chobanian & Avedisian School of Medicine, Boston Medical Center, Boston, MA, USA.
David W LounsburyDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Lisa NewmanRTI International, Research Triangle Park, NC, USA.
Katrina NickelsDepartment of Internal Medicine, University of Kentucky College of Medicine, Lexington, KY, USA.
Emmanuel A OgaRTI International, Research Triangle Park, NC, USA.
Devin A OllerDepartment of Internal Medicine, University of Kentucky College of Medicine, Lexington, KY, USA.
Theodore V ParranCase Western Reserve University School of Medicine, Department of Family Medicine and Community Health, Cleveland, Cleveland, OH, USA.
Maria QuinnHolyoke Medical Center, Holyoke, MA, USA.
Kelly S RamseyNew York HCS Community Advisory Board, New York, NY, USA.
Bruce D RapkinDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Pamela SalsberryThe Ohio State University, College of Public Health, Columbus, OH, USA.
Michael SteinDepartment of Health Law, Policy & Management, Boston University School of Public Health, Boston, MA, USA.
Jessica L TaylorSection of General Internal Medicine, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine and Boston Medical Center, Boston, MA, USA.
Julie TeaterCollege of Medicine, The Ohio State University, Columbus, OH, USA.
Scott T WaltersUniversity of North Texas Health Science Center, Fort Worth, TX, USA.
Gary A ZarkinRTI International, Research Triangle Park, NC, USA.
Nabila El-BasselColumbia University, Social Intervention Group, School of Social Work, New York, NY, USA.
T John WinhusenUniversity of Cincinnati College of Medicine, Department of Psychiatry and Behavioral Neuroscience, Cincinnati, OH, USA.
Jeffrey H SametSection of General Internal Medicine, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine and Boston Medical Center, Boston, MA, USA; Boston University School of Public Health, Boston, MA, USA.
Sharon L WalshDepartment of Behavioral Science, Center on Drug and Alcohol Research, University of Kentucky, Lexington, KY, USA.

Funding

MassHEAL - Reducing overdose deaths by 40% (2019-2023)UM1DA049412 · NIDA · BOSTON MEDICAL CENTER · PI SAMET, JEFFREY H. · 2019 to 2023
$82.9M
Kentucky CAN HEAL (Communities and Networks Helping End Addiction Long-term)UM1DA049406 · NIDA · UNIVERSITY OF KENTUCKY · PI WALSH, SHARON L. · 2019 to 2022
$81.7M
CHASE: An Innovative County-Level Public Health Response to the Opioid Epidemic in New York StateUM1DA049415 · NIDA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI EL-BASSEL, NABILA, GILBERT, LOUISA · 2019 to 2023
$77.3M
Optimizing HEALing in Ohio Communities (OHiO)-Health Equity SupplementUM1DA049417 · NIDA · OHIO STATE UNIVERSITY · PI FREISTHLER, BRIDGET J, WINHUSEN, T JOHN · 2019 to 2023
$66.3M
HEALing Communities Study Health Equity ResearchUM1DA049394 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI GLASGOW, LASHAWN, KNOTT, CHARLES · 2019 to 2023
$40.6M
NIDA NIH HHS UM1 DA049394NIDA NIH HHS UM1 DA049406NIDA NIH HHS UM1 DA049412NIDA NIH HHS UM1 DA049415NIDA NIH HHS UM1 DA049417
6 · The paper itself

Abstract

Medications for opioid use disorder (MOUD) can reduce opioid use and overdose deaths. This study examined whether the Communities That HEAL (CTH) intervention increased MOUD initiation, retention, and linkage. The HEALing Communities Study was a multi-site, 2-arm, parallel, community-level, cluster-randomized, unblinded, wait-list controlled trial conducted in 67 communities (n = 34 intervention, n = 33 control). Using Prescription Drug Monitoring Programs and Medicaid claims data, we compared mean community-level rates of MOUD outcomes during the 1-year comparison period (July 2021-June 2022) for: (a) MOUD receipt at least once; (b) continuous MOUD receipt for 180 days; and (c) MOUD linkage within 31 days following an opioid-related emergency department or hospital encounter. For intervention and control communities, adjusted rates of receiving MOUD at least once were 578 (95 % CI: 562, 594) and 596 (95 % CI: 572, 621) per 1000 Medicaid enrollees, respectively [adjusted Relative Rate (aRR)= 0.97 (95 % CI: 0.93, 1.01)]. Adjusted rates of receiving MOUD for 180 consecutive days (retention) were 614 (95 % CI: 595, 634) and 620 (95 % CI: 603, 638) per 1000 Medicaid enrollees receiving MOUD at least once for intervention and control communities, respectively [aRR= 0.99 (95 % CI: 0.95, 1.04)]. The adjusted rate of linkage was 280 (95 % CI: 254, 310) and 252 (95 % CI: 226, 281) per 1000 encounters for intervention and control communities, respectively [aRR= 1.11 (95 % CI: 0.96, 1.28). Compared to control communities, communities that received the CTH intervention did not demonstrate higher rates of MOUD use, retention, or linkage. Additional efforts are needed to improve uptake and sustained use of MOUD.

trial registrationClinicalTrials.gov Identifier: NCT04111939.

Indexed as

Narcotic AntagonistsOpiate Substitution TreatmentOpioid-Related DisordersAdultBuprenorphineFemaleHumansMaleMedicaidMiddle AgedUnited StatesWaiting ListsBuprenorphineNarcotic AntagonistsCommunities That HEAL interventionHEALing Communities StudyMedications for opioid use disorderOpioid use disorder

Identifiers

PMID40684522
PMCPMC12302724

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.