Evidence map›Paper›PMID 40684465›Full record

ArticleChemistry & biodiversity2025

Exploring Bioactive Metabolites From Fusarium falciforme and Aspergillus terreus Isolated From Protease-Rich Fruits: Antifungal, Antitrypanosomal, and Enzymatic Inhibitory Activities.

Gabriela de Oliveira Almeida, Vitor de Souza Mazucato, Ludmilla Tonani, Marcia Regina von Zeska Kress, Gisele Barbosa, Renata Krogh, Adriano Defini Andricopulo, Leonardo Luiz Gomes Ferreira, Paulo Cezar Vieira

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gabriela de Oliveira AlmeidaDepartment of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-9243-9509
Vitor de Souza MazucatoDepartment of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-9859-8551
Ludmilla TonaniDepartment of Clinical Analysis, Toxicology, and Food Science, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-6892-8962
Marcia Regina von Zeska KressDepartment of Clinical Analysis, Toxicology, and Food Science, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-1239-7722
Gisele BarbosaSão Carlos Institute of Physics, University of São Paulo, São Carlos, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-9431-2627
Renata KroghSão Carlos Institute of Physics, University of São Paulo, São Carlos, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-6545-608X
Adriano Defini AndricopuloSão Carlos Institute of Physics, University of São Paulo, São Carlos, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-0457-818X
Leonardo Luiz Gomes FerreiraSão Carlos Institute of Physics, University of São Paulo, São Carlos, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-6947-0639
Paulo Cezar VieiraDepartment of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-4207-6217

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Finance Code 001Fundação de Amparo à Pesquisa do Estado de São Paulo # 2023/12463-7
6 · The paper itself

Abstract

Fungal secondary metabolites display remarkable chemical diversity and biological potential, with applications in agriculture and pharmaceuticals. This study isolated and characterized bioactive metabolites from two phytopathogenic fungi, Fusarium falciforme (from papaya) and Aspergillus terreus (from pineapple), assessing their antifungal and cysteine protease-inhibitory activities. The compounds hymeglusin, fusaridioic acid A, and butyrolactone I exhibited significant antifungal effects, with hymeglusin (IC

Indexed as

Antifungal AgentsAspergillusFruitFusariumPeptide HydrolasesTrypanocidal AgentsAcyl-ButyrolactonesDose-Response Relationship, DrugFatty AcidsMicrobial Sensitivity TestsMolecular StructureStructure-Activity RelationshipTrypanosoma brucei bruceiAcyl-ButyrolactonesAntifungal AgentsFatty AcidshymeglusinPeptide HydrolasesTrypanocidal Agentsantifungal | antiparasitic activity | phytopathogenic fungi | protease inhibition | secondary metabolites

Identifiers

PMID40684465
PMCPMC12629174

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.