ArticleAnnals of medicine2025
Reference interval of serum uric acid among healthy children and adolescents in Nanjing, China, and influencing factors.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReference interval for serum uric acid (SUA) in children is based on adult standards. This study aimed to determine the reference interval and influencing factors of SUA in healthy children and adolescents.
methodsFrom August 2020 to August 2022, 7,742 healthy children and adolescents aged 3-15 years receiving physical examinations at the Children's Health Care Department at Children's Hospital of Nanjing Medical University were recruited. A reference interval of SUA among children and adolescents was determined and validated in a cohort of 2,968 children. Influencing factors of SUA levels were identified by linear regression analyses.
resultsAmong 7,742 healthy children and adolescents with an average age of 8.2 ± 2.3 years, the average SUA level was 4.5 ± 0.98 mg/dl, and significantly higher in boys than girls. Age-specific increase in the SUA level started from the age of 8 years. A significantly higher SUA level was detected in boys than in girls among those older than 12 years. The reference interval of SUA among healthy children and adolescents in the age groups of 3-8 years, 9-10 years, 11 years was established as 2.8-6.1 mg/dl, 2.9-6.4 mg/dl, and 3.1-7.4 mg/dl, respectively. For those aged 12-15 years, the reference interval of SUA was 3.5-8.7 mg/dl in boys and 3.4-7.7 mg/dl in girls. Linear regression analysis indicated that SUA was positively correlated with the body fat percentage, skeletal muscle mass, and alanine aminotransferase, while negatively correlated with estimated glomerular filtration rate.
conclusionThe distributions of SUA levels are age and gender-specific among healthy children and adolescents in Nanjing, China. The established distinct reference interval of SUA and diagnostic criteria for hyperuricemia in this population may assist in the clinical management of related diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.