ArticleCerebral cortex (New York, N.Y. : 1991)2025
Molecular and cellular rhythms in excitatory and inhibitory neurons in the mouse prefrontal cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Defining Clock Neurons Within Distributed Circadian Circuits Through Multiscale Technologies.Journal of biological rhythms · 2026Review
- Brief high-fat diet exposure temporally reshapes affective behavior and prefrontal cortex function.bioRxiv : the preprint server for biology · 2026Article
- Parvalbumin interneurons mediate sex differences in prefrontal cortex function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
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12 authors.
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Abstract
While previous studies have found rhythms in gene expression in the prefrontal cortex (PFC), the contribution of different cell types and potential variation by sex has not been determined. Of interest are excitatory pyramidal cells and inhibitory parvalbumin (PV) interneurons, as the interaction between these cells is thought to underlie gamma oscillations and play a role in schizophrenia. We identify cell-type-specific rhythms in ribosome-associated transcripts from PV and pyramidal cells in the mouse PFC and assess rhythms in PV cell electrophysiology. We find that while core molecular clock genes are synchronized between cell types, pyramidal cells have nearly twice as many rhythmic transcripts as PV cells (35% vs. 18%). Moreover, in contrast to PV cells, rhythmic transcripts in pyramidal cells show substantial overlap between sexes. Additionally, there is a sex-specific reduction in action potential amplitude and spike frequency adaptation during the dark phase in PV cells from females. This study demonstrates that rhythms in gene expression and electrophysiological properties in the PFC vary by cell type and by sex. Moreover, the biological processes associated with rhythmic transcripts may provide insight into the unique functions of rhythms in these cells, as well as their selective vulnerabilities to circadian disruption.
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