Evidence map›Paper›PMID 40684230›Full record

Trial reportAddiction science & clinical practice2025

Usability and cultural adaptation of a text message-based tobacco cessation intervention for people living with HIV in Uganda and Zambia.

Heather Wipfli, Jim Arinaitwe, Fastone Goma, Lynn Atuyambe, David Guwatudde, Masauso Moses Phiri, Elizeus Rutebemberwa, Fred Wabwire-Mangen, Richard Zulu, Cosmas Zyambo and 5 more

Registry-linked trialAbstract readClinical Trial, Phase IRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Addiction science & clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05487807 (Quit4Life+), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05487807 phase1recruitingnot on this map

Quit4Life+: Adapting and Evaluating a Phone-Based Tobacco Use Cessation Program for People Living With HIV in Uganda and Zambia (Quit4Life+ )

TypeinterventionalSponsorUniversity of Southern CaliforniaRan2023 to 2026Enrolled800ConditionsNicotine Dependence, Tobacco DependenceArmsNicotine patch, text messaging
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Heather WipfliDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, 2001 N. Soto Street, Los Angeles, CA, 90033, USA. hwipfli@usc.edu.ORCID 0000-0001-9020-2033
Jim ArinaitweSchool of Public Health, Centre for Tobacco Control in Africa, Makerere University, Kampala, Uganda.
Fastone GomaSchool of Medicine, Centre For Primary Care Research, University of Zambia, Lusaka, Zambia.
Lynn AtuyambeDepartment of Community Health and Behavioural Sciences, School of Public Health, Makerere University, Kampala, Uganda.
David GuwatuddeDepartment of Epidemiology and Biostatistics, Makerere University School of Public Health, Kampala, Uganda.
Masauso Moses PhiriSchool of Medicine, Centre For Primary Care Research, University of Zambia, Lusaka, Zambia.
Elizeus RutebemberwaDepartment of Health Policy, Planning, and Management, School of Public Health, Makerere University, Kampala, Uganda.
Fred Wabwire-MangenDepartment of Epidemiology and Biostatistics, Makerere University School of Public Health, Kampala, Uganda.
Richard ZuluSchool of Medicine, Centre For Primary Care Research, University of Zambia, Lusaka, Zambia.
Cosmas ZyamboDepartment of Community and Family Medicine, School of Public Health, University of Zambia, Lusaka, Zambia.
Kyra GuyDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, 2001 N. Soto Street, Los Angeles, CA, 90033, USA.
Ronald KusoloSchool of Public Health, Centre for Tobacco Control in Africa, Makerere University, Kampala, Uganda.
Musawa MukupaSchool of Medicine, Centre For Primary Care Research, University of Zambia, Lusaka, Zambia.
Ezekiel MusasiziSchool of Public Health, Centre for Tobacco Control in Africa, Makerere University, Kampala, Uganda.
Joan S TuckerRAND Corporation, Santa Monica, CA, USA.

Funding

Understanding Stigma as a barrier to cancer prevention and treatment in Uganda and ZambiaU01CA261624 · NCI · UNIV OF MARYLAND, COLLEGE PARK · PI WIPFLI, HEATHER L · 2021 to 2025
$3.7M
NCI NIH HHS U01 CA261624NCI NIH HHS U01CA261624
6 · The paper itself

Abstract

backgroundText messaging-based interventions (TMIs) have demonstrated effectiveness in reducing tobacco use in many populations. However, such interventions have not been tailored to meet the complex medical and psychosocial factors confronting people living with HIV (PLWH) in sub-Saharan Africa (SSA). We describe the process of adapting the SmokefreeTXT message library so that it is applicable to all forms of tobacco use, addresses issues specifically facing PLWH who use tobacco, and is culturally appropriate for use in Uganda and Zambia. METHODS/

designParticipants were PLWH who currently used tobacco and health services workers recruited from HIV clinics in two regions of Uganda and two regions of Zambia. Eight focus groups (N = 48) were conducted with PLWH tobacco users and four focus groups (N = 28) were conducted with healthcare providers to adapt the TMI content for the cultural context and HIV status. A subsample of PLWH focus group participants (N = 14) provided feedback on the adapted TMI after using it for three weeks on their own phone. Focus group transcripts were analyzed for key themes based on the moderator guides using Dedoose software™. Means and percentages were calculated for survey data to assess the TMI's acceptability and feasibility.

resultsFocus group feedback on facilitators and barriers to quitting tobacco, as well as strengths and limitations of the TMI-based intervention approach, were used to finalize the adapted TMI's content and delivery for usability testing. PLWH identified multiple barriers to quitting tobacco including addiction, lack of support and education, and community perceptions. Health service workers highlighted the need for community-level interventions, improved provider knowledge on tobacco cessation, and tailored support strategies. Usability testing participants rated the TMI as helpful and relevant, emphasizing the interactive features as supportive and beneficial. Further, they reported few problems using it over three weeks, except for difficulty keeping their phone charged.

conclusionsResults suggest that an adapted version of SmokefreeTXT is a feasible and acceptable option for PLWH in Uganda and Zambia who are interested in quitting tobacco use.

trial registrationClinicalTrials.gov Identifier NCT05487807. Registered August 4, 2022, https://clinicaltrials.gov/ct2/show/record/NCT05487807.

Indexed as

HIV InfectionsSmoking CessationText MessagingTobacco Use CessationAdultFemaleFocus GroupsHumansMaleMiddle AgedUgandaZambiaCessationHIVInterventionSub-Saharan AfricaText messagingTobacco

Identifiers

PMID40684230
PMCPMC12276659

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.