ArticleCell & bioscience2025
Circ_HUWE1: a novel regulator of lipid accumulation, inflammation, and gut microbiota in atherosclerosis.
Article in Cell & bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Predicting all-cause and cardiovascular mortality in hypertensive patients by combining the CHG index and its obesity indicators: a prospective cohort study with survival prediction model.Cardiovascular diabetology · 2026Article
- Yiqihuoxue formula improves atherosclerosis by regulating macrophage polarization associated with enhanced STAT6/PPARγ pathway.Frontiers in cardiovascular medicine · 2026Article
- The role of HECT-type E3 ubiquitin ligases in inflammation.Frontiers in immunology · 2026Review
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Authors and funding
7 authors.
Funding
Abstract
backgroundAtherosclerosis (AS) is a chronic cardiovascular disease characterized by lipid accumulation and inflammation within arterial walls, leading to plaque formation and cardiovascular events. Circular RNAs (circRNAs) have emerged as key regulators in various diseases, but their role in AS remains poorly understood. This study investigates the protective role and underlying mechanism of circ_HUWE1 in lipid metabolism, macrophage infiltration, inflammation, and gut microbiota modulation in AS.
methodsCirc_HUWE1 expression was evaluated in coronary artery disease (CAD) patients and in fecal samples from AS patients. An ApoE
resultsCirc_HUWE1 expression was significantly downregulated in CAD patients, fecal samples of AS patients and in HFD-fed ApoE
conclusionOur study demonstrates for the first time that circ-HUWE1 exerts a protective effect against atherosclerosis by regulating lipid metabolism, macrophage infiltration and inflammatory responses through the miR-143-3p/IGFBP5 axis and reshaping the gut microbiota. These findings suggest circ_HUWE1 as a potential therapeutic target for atherosclerosis treatment.
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