Evidence map›Paper›PMID 40684141›Full record

ArticleBMC oral health2025

The key target and role of betel nut in oral squamous cell carcinoma.

Tianyi Zhang, Haofeng Xiong, Liujun Zeng, Zhimin Yang, Xin Hu, Tong Su

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Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tianyi ZhangDepartment of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, No.87 Xiangya Road, Changsha, 410008, Hunan, China.
Haofeng XiongDepartment of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, No.87 Xiangya Road, Changsha, 410008, Hunan, China.
Liujun ZengDepartment of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, No.87 Xiangya Road, Changsha, 410008, Hunan, China.
Zhimin YangDepartment of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, No.87 Xiangya Road, Changsha, 410008, Hunan, China.
Xin HuDepartment of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, No.87 Xiangya Road, Changsha, 410008, Hunan, China. huxins@csu.edu.cn.ORCID http://orcid.org/0000-0003-1430-0672
Tong SuDepartment of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, No.87 Xiangya Road, Changsha, 410008, Hunan, China. sutong@csu.edu.cn.ORCID http://orcid.org/0000-0001-7466-3999

Funding

National Clinical Medical Research Center for Geriatric Diseases 2021LNJJ08National Natural Science Foundation of China 82170973Natural Science Foundation of Hunan Province 2025JJ60597
6 · The paper itself

Abstract

backgroundBetel nut consumption is closely related to oral cancer. This study aimed to explore the crucial target and role of betel nut in oral cancer.

methodsWe used RNA sequencing and protein-protein interaction networks to screen the key target of betel nut in oral cancer. Enrichment analysis was used to explore the role of betel nut. Immunohistochemical analysis was used to identify the expression trend of the key target, and survival analysis was used to explore the prognostic value of the key target. The animal model of oral cancer was used to verify the key target of betel nut.

resultsFirstly, 1108 genes were differentially expressed in oral cancer under the influence of betel nut, which may be involved in "metabolic pathways." Moreover, TP53 was the key target of betel nut and was upregulated, resulting in poor prognosis in patients with oral cancer. Finally, the differential expression and role of TP53 in oral cancer with betel nut were validated by human and animal samples.

conclusionsIn conclusion, we found that TP53 upregulation may be the crucial biological phenomenon in the oral cancer with betel nut, indicating that TP53 may be the key target of betel nut in oral cancer.

Indexed as

ArecaCarcinoma, Squamous CellMouth NeoplasmsAnimalsFemaleHumansMaleMiceNutsPrognosisProtein Interaction MapsTumor Suppressor Protein p53Tumor Suppressor Protein p53Betel nutOral squamous cell carcinomaTP53

Identifiers

PMID40684141
PMCPMC12276680

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.