Evidence map›Paper›PMID 40684118›Full record

ArticleBMC oral health2025

Evaluation of the osteogenic effect of Naringin-enhanced bmscs/cpc composite for alveolar ridge preservation and tooth extraction wound healing in beagle dogs.

Xin Yang, Peng Sun, Deming Yu, Xinjie Liang, Xuebin Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xin YangDepartment of Oral and Maxillofacial Surgery, The affiliated Yantai Stomatological Hospital, Binzhou Medical University, No. 142 North Great Street, Zhifu District, Yantai, 264003, P.R. China.
Peng SunDepartment of Oral and Maxillofacial Surgery, The affiliated Yantai Stomatological Hospital, Binzhou Medical University, No. 142 North Great Street, Zhifu District, Yantai, 264003, P.R. China.
Deming YuDepartment of Oral and Maxillofacial Surgery, The affiliated Yantai Stomatological Hospital, Binzhou Medical University, No. 142 North Great Street, Zhifu District, Yantai, 264003, P.R. China.
Xinjie LiangDepartment of Oral and Maxillofacial Surgery, Yantai Yuhuangding Hospital, Yantai, 264000, P.R. China.
Xuebin ZhangDepartment of Oral and Maxillofacial Surgery, The affiliated Yantai Stomatological Hospital, Binzhou Medical University, No. 142 North Great Street, Zhifu District, Yantai, 264003, P.R. China. zhaohuiwzj@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to evaluate the osteoinductive potential of a composite material consisting of Naringin, bone marrow stromal cells (BMSCs), and calcium phosphate cement (CPC) for alveolar ridge preservation and tooth extraction wound healing in Beagle dogs. MATERIALS AND

methodsSix Beagle dogs underwent bilateral extraction of the mandibular first through fourth premolars. The extraction sites were treated with one of the following: Naringin/BMSCs + CPC, BMSCs + CPC, blank control, and Bio-Oss. Samples were collected at 4, 8, and 12 weeks, with two dogs per time point. Evaluations included gross examination, cone-beam computed tomography (CBCT), micro-computed tomography (Micro-CT), and histological analysis.

resultsCBCT revealed minimal alveolar ridge changes in the Naringin/BMSCs + CPC and Bio-Oss groups, while significant resorption was observed in the control group. Micro-CT showed superior bone volume fraction, trabecular number, and bone mineral density in the experimental groups compared to the control group. Histology confirmed higher new bone formation in the Naringin/BMSCs + CPC and Bio-Oss groups.

conclusionThe Naringin/BMSCs/CPC composite showed significant osteogenic potential, promoting extraction site healing and enhancing alveolar ridge regeneration. This composite may serve as a viable option for clinical alveolar ridge preservation. CLINICAL RELEVANCE: The Naringin/BMSCs/CPC composite may provide a promising approach for preserving alveolar ridges and enhancing bone regeneration in clinical dental practices, potentially improving outcomes for patients undergoing tooth extractions.

Indexed as

Alveolar ProcessCalcium PhosphatesFlavanonesOsteogenesisTooth ExtractionWound HealingAnimalsCone-Beam Computed TomographyDogsMesenchymal Stem CellsMineralsTooth SocketX-Ray MicrotomographyBio-Osscalcium phosphateCalcium PhosphatesFlavanonesMineralsnaringinAlveolar ridge preservationBone marrow stromal cellsCalcium phosphate cementNaringinTooth extractionWound healing

Identifiers

PMID40684118
PMCPMC12275350

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.