ArticleBMC nephrology2025
Population risk predictors of major adverse kidney events attributed to focal segmental glomerulosclerosis from the CURE-CKD registry.
Article in BMC nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPredictors of major adverse kidney events (MAKE) in focal segmental glomerulosclerosis (FSGS) have not been previously explored within large, real-world populations. The study aim was to evaluate population-level predictors of MAKE attributed to FSGS from health system data.
methodsThe study population was derived from electronic health records from Providence and University of California Los Angeles Health Systems. Identification of FSGS was based on International Classification of Diseases 9/10 diagnostic codes. Cox proportional hazards models were used to estimate the effects of traditional clinical and unique non-traditional variables including age, gender, race and ethnicity, health system, health insurance, healthcare utilization, estimated glomerular filtration rate (eGFR), diabetes, hypertension, and prescription medications as predictors of MAKE defined as: ≥ 40% eGFR decline, kidney failure (eGFR < 15 mL/min/1.73 m
resultsAdults with FSGS (N = 629) were 54% (n = 342) men and 53 ± 17 (mean ± SD) years old. Baseline eGFR was 60 ± 30 mL/min/1.73 m
conclusionsSubstantial loss of kidney function or kidney failure occurred in more than four in ten patients with FSGS by a median of three years. MAKE were predicted by unique population level factors, such as healthcare utilization and insurance type, which may help to identify patients with FSGS, who could most benefit from diagnostic testing and interventions to improve clinical outcomes. CLINICAL TRIAL NUMBER: Not applicable.
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