ArticleBMC cardiovascular disorders2025
Prevalence and clinical risk factors of cardiovascular disease in patients with cancer: a cross-sectional study.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Persistent Cardiovascular Burden and Independent Association Among Cancer Survivors in the United States, 2016 to 2024.Journal of the American Heart Association · 2026Article
- Over-presentation of apolipoprotein E gene variants E3/E4 and cardiovascular disease risk factors among Ghanaian breast cancer patients.BMC cancer · 2026Article
- Innovative strategies for early detection of cardiotoxicity: artificial intelligence and multi-modality collaborative models.Journal of thrombosis and thrombolysis · 2026Review
- Exosomal lncRNA FENDRR Orchestrates Immune Remodelling and Ferroptosis in the Comorbidity of Lung Cancer and Type 1 Myocardial Infarction.Human mutation · 2026Article
- Malnutrition, cachexia and sarcopenia as susceptibility factors for cardiovascular complications in patients with cancer.Frontiers in pharmacology · 2026Review
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4 authors.
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Abstract
objectiveThis study aimed to investigate the prevalence of common cardiovascular diseases (CVDs) and their clinical risk factors among patients with cancer and to offer clinical evidence to help manage CVD within this population.
methodsPatients with cancer who were aged ≥ 20 years were selected from the National Health and Nutrition Examination Survey (NHANES) 2015-2020. The prevalence of CVD and its components was analyzed using weighted analysis to obtain standardized prevalence. Subgroup analyses for gender and age were also performed. Lastly, the clinical risk factors for CVD in patients with cancer were identified by conducting multivariable logistic regression.
resultsA total of 1729 individuals diagnosed with cancer were included, among which 432 had CVD. Weighted analysis further revealed that 21.21% (95%CI: 17.55-24.86) of the patients with cancer had CVD. Moreover, CVD prevalence was 25.12% in males and 18.30% in females (P = 0.01), while it was 26.93% in the age group of ≥ 65 years and 14.58% in the < 65 years age group (P < 0.001). In terms of CVD components, angina pectoris was diagnosed in 4.51% of the patients, myocardial infarction in 8.56%, coronary heart disease in 10.09%, heart failure in 5.08%, and stroke in 7.57%. Multivariable logistic regression analysis indicated that older age (OR = 1.02, 95% CI: 1.01-1.03), smoking history (OR = 1.56, 95% CI: 1.02-2.39 for former smoking and OR = 2.82, 95% CI: 1.59-5.01 for current smoking), hypertension (OR = 2.78, 95% CI: 1.81-4.28), diabetes (OR = 2.04, 95% CI: 1.47-2.84), chronic kidney disease (CKD, OR = 1.73, 95% CI: 1.28-2.34), and antineoplastic or other treatments (OR = 4.83, 95% CI: 2.15-10.85) were statistically significant independent risk factors for CVD in patients with cancer.
conclusionsPatients with cancer have a weighted CVD prevalence of 21.21%, with male patients and those ≥ 65 years demonstrating a higher prevalence of CVD. Independent clinical risk factors for CVD in patients with cancer comprise age, smoking history, hypertension, diabetes, CKD, and antineoplastic or other treatments.
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