Evidence map›Paper›PMID 40684080›Full record

ArticleBMC pregnancy and childbirth2025

Characteristics of eclampsia not preceded by hypertensive disorders of pregnancy: a case control study.

Maki Sato, Kaori Iino, Takashi Ozaki, Tetsuji Hashimoto, Yuki Osawa, Rikako Hashimoto, Tomoe Tando, Aisa Takeda, Sota Takahashi, Ryosuke Taniguchi and 5 more

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In one paragraph

Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Maki SatoDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Hirosaki University, 5 Zaifu, Hirosaki, Aomori, 036-8562, Japan.
Kaori IinoDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Hirosaki University, 5 Zaifu, Hirosaki, Aomori, 036-8562, Japan. iino-ka@hirosaki-u.ac.jp.ORCID http://orcid.org/0000-0002-0962-1159
Takashi OzakiPerinatal Maternal and Child Center, Aomori Prefectural Central Hospital, Aomori, Japan.
Tetsuji HashimotoDepartment of Obstetrics and Gynecology, Aomori City Hospital, Aomori, Japan.
Yuki OsawaDepartment of Obstetrics and Gynecology, Odate Municipal General Hospital, Akita, Japan.
Rikako HashimotoDepartment of Obstetrics and Gynecology, Kensei Hospital, Aomori, Japan.
Tomoe TandoDepartment of Obstetrics and Gynecology, Hirosaki General Medical Center, Aomori, Japan.
Aisa TakedaDepartment of Obstetrics and Gynecology, Mutsu General Hospital, Aomori, Japan.
Sota TakahashiDepartment of Obstetrics and Gynecology, Hachinohe City Hospital, Aomori, Japan.
Ryosuke TaniguchiDepartment of Obstetrics and Gynecology, Tsugaru General Hospital, Aomori, Japan.
Maika OishiDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Hirosaki University, 5 Zaifu, Hirosaki, Aomori, 036-8562, Japan.
Asami ItoPerinatal Medical Center, Hirosaki University Hospital, Aomori, Japan.
Kanji TanakaPerinatal Medical Center, Hirosaki University Hospital, Aomori, Japan.
Tetsu TomitaDepartment of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Aomori, Japan.
Yoshihito YokoyamaDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Hirosaki University, 5 Zaifu, Hirosaki, Aomori, 036-8562, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEclampsia is traditionally considered a complication of hypertensive disorders of pregnancy (HDP). However, atypical cases occur without preceding HDP, and their pathophysiological mechanisms remain unclear. This study aimed to compare the clinical features of eclampsia with and without prior HDP diagnosis.

methodsWe retrospectively analyzed 31 singleton pregnancies with eclampsia diagnosed at nine Japanese perinatal centers between 2007 and 2023. Cases were classified into two groups: eclampsia preceded by HDP (n = 14) and eclampsia not preceded by HDP (n = 17). Clinical characteristics, laboratory findings, and perinatal outcomes were compared.

resultsOf the 31 cases of eclampsia, 17 (57%) were not preceded by HDP, while the remaining cases had been diagnosed with HDP prior to the onset of eclampsia. In the eclampsia not preceded by HDP group, compared to the eclampsia preceded by HDP group, the BMI was significantly lower (22.07 ± 2.05 vs. 25.60 ± 6.19 kg/m

conclusionsAtypical eclampsia without preceding HDP shows distinct clinical features, including later gestational age at onset, higher intrapartum incidence, and elevated inflammatory markers. These findings suggest a need for further investigation into alternative pathophysiological mechanisms and tailored clinical strategies for such cases.

Indexed as

EclampsiaHypertension, Pregnancy-InducedAdultCase-Control StudiesFemaleGestational AgeHumansInfant, NewbornJapanMalePregnancyPregnancy OutcomeRetrospective StudiesEclampsiaImmunityMaternal mortalityPregnancy-induced hypertensionRetrospective studyRisk FactorsSeizures

Identifiers

PMID40684080
PMCPMC12275242

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.