ArticleCommunications medicine2025
Common inflammatory proteins linking frailty and area-level deprivation as key drivers of cardiovascular risk in women.
Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Plasma cytokine profiles in breast cancer patients and their association with therapeutic response in Peru: a prospective cohort study.Frontiers in immunology · 2026Article
- Association between triglyceride-glucose index-a body shape index and atherosclerotic cardiovascular disease, and the modification effect of dietary patterns.Frontiers in nutrition · 2026Article
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Authors and funding
13 authors.
Funding
Abstract
backgroundChronic inflammation is linked to frailty and deprivation, both of which are comorbid with cardiovascular diseases (CVD). This study aims to identify inflammatory proteins associated with both socioeconomic deprivation and frailty, and assess their role in mediating cardiovascular risk in a large cohort with independent replication.
methodsWe included 2144 TwinsUK females aged 37-84 with concurrent measures of frailty (frailty index), index of multiple deprivation (IMD), cardiovascular risk (ASCVD score), and 74 proteins (Olink inflammation panel). A random forest model with SHapley Additive exPlanations identified shared proteomic markers of frailty and deprivation. Linear mixed models assessed associations between selected proteins, IMD, frailty, and ASCVD score. Findings were validated in 57 females from the Nottingham Osteoarthritis study. Mixed-effects Cox regression evaluated associations with 10-year ischemic heart disease risk, and mediation analysis assessed the role of proteins in linking IMD and frailty to ASCVD risk.
resultsWe identify ten pro-inflammatory proteins associated with both frailty and area-level social deprivation. Four of those (TNFSF14, HGF, CDCP1, and CCL11) are consistently positively correlated with ASCVD score in both two cohorts. CDCP1 is also associated with higher incident ischemic heart disease risk (HR [95%CI] = 1.82 [1.17, 2.85]). TNFSF14, HGF, and CDCP1 mediate the association between IMD and ASCVD, as well as between frailty and ASCVD.
conclusionsOur findings indicate that inflammatory proteins involved in cellular signalling, growth, and migration are associated with frailty, socioeconomic deprivation, and CVD risk, suggesting that these pathways mediate the impact of socioeconomic deprivation and ageing on CVD risk.
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Registered trials
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