Evidence map›Paper›PMID 40684006›Full record

ArticleMolecular psychiatry2025

Early postnatal dysfunction of ACC PV interneurons in Shank3B

Yi-Chun Shih, Lars Nelson, Michael Janeček, Michael Matarazzo, Andrew D'Agostino, Rui T Peixoto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Yi-Chun ShihDepartment of Psychiatry, University of Pittsburgh, 450 Technology Dr, Pittsburgh, PA, 15219, USA.
Lars Nelson *Department of Psychiatry, University of Pittsburgh, 450 Technology Dr, Pittsburgh, PA, 15219, USA.
Michael Janeček *Department of Psychiatry, University of Pittsburgh, 450 Technology Dr, Pittsburgh, PA, 15219, USA.
Michael MatarazzoDepartment of Psychiatry, University of Pittsburgh, 450 Technology Dr, Pittsburgh, PA, 15219, USA.
Andrew D'AgostinoDepartment of Psychiatry, University of Pittsburgh, 450 Technology Dr, Pittsburgh, PA, 15219, USA.
Rui T PeixotoDepartment of Psychiatry, University of Pittsburgh, 450 Technology Dr, Pittsburgh, PA, 15219, USA. peixotort@upmc.edu.ORCID 0000-0002-5310-2102

Funding

Mechanisms and pathogenic role of early corticostriatal dysfunction in Shank3B-/- miceR01MH124695 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PEIXOTO, RUI · 2021 to 2025
$2.0M
Role of local interneurons in early cortical dysfunction in Shank3 KO miceR21MH132015 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PEIXOTO, RUI · 2023 to 2023
$437k
NIMH NIH HHS R01 MH124695NIMH NIH HHS R21 MH132015U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH124695U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH132015
6 · The paper itself

Abstract

Anterior cingulate cortex (ACC) dysfunction is implicated in the cognitive and social deficits associated with autism spectrum disorder (ASD), yet the developmental trajectory of ACC circuit maturation in ASD remains poorly understood. Here, we examined the postnatal development of glutamatergic synaptic connectivity and intrinsic excitability in layer 2/3 pyramidal neurons (PYRs) and Parvalbumin-expressing interneurons (PVINs) in the ACC of mice harboring a deletion in SHANK3 (Shank3B

Indexed as

Gyrus CinguliInterneuronsNerve Tissue ProteinsAnimalsAutism Spectrum DisorderDisease Models, AnimalFemaleGlutamic AcidHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMaleMiceMice, Inbred C57BLMice, KnockoutMicrofilament ProteinsParvalbuminsPyramidal CellsGlutamic AcidHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMicrofilament ProteinsNerve Tissue ProteinsParvalbuminsShank3 protein, mouse

Identifiers

PMID40684006
PMCPMC12532719

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.