Evidence map›Paper›PMID 40683922›Full record

ArticleScientific reports2025

Genetic and biochemical insights into siderophore biosynthesis in the marine fish pathogen Tenacibaculum maritimum.

M Pilar Escribano, Lucía Ageitos, Miguel Balado, Larissa Buedenbender, Jaime Rodríguez, Carlos Jiménez, Beatriz Magariños, Manuel L Lemos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

M Pilar EscribanoDepartment of Microbiology and Parasitology, Aquatic One Health Research Center (ARCUS), Universidade de Santiago de Compostela, Santiago de Compostela, 15782, Spain.
Lucía AgeitosDepartmento de Química, Facultad de Ciencias and CICA - Centro Interdisciplinar de Química e Bioloxía, Universidade da Coruña, 15071, A Coruña, Spain.
Miguel BaladoDepartment of Microbiology and Parasitology, Aquatic One Health Research Center (ARCUS), Universidade de Santiago de Compostela, Santiago de Compostela, 15782, Spain.
Larissa BuedenbenderDepartmento de Química, Facultad de Ciencias and CICA - Centro Interdisciplinar de Química e Bioloxía, Universidade da Coruña, 15071, A Coruña, Spain.
Jaime RodríguezDepartmento de Química, Facultad de Ciencias and CICA - Centro Interdisciplinar de Química e Bioloxía, Universidade da Coruña, 15071, A Coruña, Spain.
Carlos JiménezDepartmento de Química, Facultad de Ciencias and CICA - Centro Interdisciplinar de Química e Bioloxía, Universidade da Coruña, 15071, A Coruña, Spain.
Beatriz MagariñosDepartment of Microbiology and Parasitology, Aquatic One Health Research Center (ARCUS), Universidade de Santiago de Compostela, Santiago de Compostela, 15782, Spain. beatriz.magarinos@usc.es.
Manuel L LemosDepartment of Microbiology and Parasitology, Aquatic One Health Research Center (ARCUS), Universidade de Santiago de Compostela, Santiago de Compostela, 15782, Spain. manuel.lemos@usc.es.

Funding

Agencia Estatal de Investigación,Spain PID2021-122732OB-C21Agencia Estatal de Investigación,Spain PID2021-122732OB-C22HORIZON EUROPE Marie Sklodowska-Curie Actions,European Union 101066127Ministerio de Ciencia e Innovación,Spain PRE2019-089544Xunta de Galicia,Spain ED431C 2022/023Xunta de Galicia,Spain ED431C 2022/039Xunta de Galicia,Spain ED481B 2024/076
6 · The paper itself

Abstract

Siderophore production is a key fitness trait for bacteria, particularly in iron-limited environments such as marine ecosystems and host tissues. In this study, we identify the tenABECDC2D2hp1-4 gene cluster as responsible for siderophore biosynthesis in Tenacibaculum maritimum, confirmed through genome analysis and a tenCD-inactivated mutant. This cluster, highly similar to the desferrioxamine biosynthesis system in Streptomyces coelicolor, features a unique tenCD duplication/fusion, essential for siderophore formation. Additionally, accessory genes (hp1-4) encode functions such as nitroreductase and N-acetyltransferase, likely contributing to siderophore diversification. LC/MS analysis of T. maritimum cultures revealed the production of 20 amphiphilic, acylated desferrioxamine-like siderophores. These findings provide new insights into the genetic and metabolic versatility of marine pathogens in iron acquisition.

Indexed as

Biosynthetic PathwaysSiderophoresTenacibaculumAnimalsBacterial ProteinsDeferoxamineFishesFlavobacteriaceae InfectionsGenes, BacterialIronMultigene FamilyMutationSeawaterBacterial ProteinsDeferoxamineIronSiderophoresDesferrioxamineIron acquisitionMarine siderophoresTenacibaculosisTenacibaculum maritimum

Identifiers

PMID40683922
PMCPMC12276236

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.