Evidence map›Paper›PMID 40683901›Full record

ArticleScientific reports2025

BACES score: a predictor of health-related quality of life and associated factors in patients with nontuberculous mycobacterial pulmonary disease.

Youngmok Park, Nakwon Kwak, Hyeontaek Hwang, Doosoo Jeon, Byung Woo Jhun, Kyung-Wook Jo, Young Ae Kang, Hyung-Jun Kim, Joong-Yub Kim, Young Ran Kim and 10 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Youngmok ParkDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Nakwon KwakDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Hyeontaek HwangDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Doosoo JeonDepartment of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Republic of Korea.
Byung Woo JhunDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Kyung-Wook JoDivision of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Young Ae KangDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Hyung-Jun KimDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Joong-Yub KimDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Young Ran KimDivision of Clinical Research, International Tuberculosis Research Centre, Seoul, Republic of Korea.
Yong-Soo KwonDepartment of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea.
Jae Ho LeeDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Tae Sun ShimDivision of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Hojoon SohnDepartment of Preventive Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea.
Jake WhangKorea Mycobacterium Resource Center and Basic Research Section, The Korean Institute of Tuberculosis, Cheongju, Republic of Korea.
Jayoun KimMedical Research Collaborating Center, Seoul National University Hospital, Seoul, Republic of Korea.
Nanhee ParkMedical Research Collaborating Center, Seoul National University Hospital, Seoul, Republic of Korea.
Gyeong In LeeLaboratory Medicine Center, The Korean Institute of Tuberculosis, Korean National Tuberculosis Association, Cheongju, Republic of Korea.
Jae-Joon YimDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Jeongha MokDivision of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Pusan National University Hospital, Busan, Republic of Korea. mokgamokga@gmail.com.

Funding

Patient-Centered Clinical Research Coordinating Center RS-2021-KH119793
6 · The paper itself

Abstract

The evaluation of health-related quality of life (HRQOL) is gaining importance among patients with nontuberculous mycobacterial pulmonary disease (NTM-PD). We assessed whether the BACES score reflects HRQOL and associated factors in these patients. Data were collected from the nationwide NTM-KOREA prospective cohort of patients with NTM-PD who started antibiotic treatment and included symptoms, Quality of Life-Bronchiectasis (QOL-B) questionnaire, nutritional status using the Mini Nutritional Assessment-Short Form (MNA-SF) and Prognostic Nutritional Index (PNI), physical activity, body composition, spirometry, handgrip strength, and 6-min walking distance. Multivariate linear and logistic regressions were used for analysis. As the BACES score increased, so did the odds (adjusted odds ratio [95% confidence interval]) of cough (1.24 [1.04-1.48]), dyspnea (1.69 [1.28-2.27]), weight loss (1.78 [1.36-2.36]), and malnutrition, defined as MNA-SF score ≤ 7 (1.71 [1.21-2.45]), and PNI < 45 (2.14 [1.66-2.81]). The QOL-B respiratory symptom score (estimate: -2.259, P = 0.002) and 6-min walking distance (estimate: -18.015, P < 0.001) were negatively associated with the BACES score. Moreover, the odds of adipopenia (1.08 [1.03-1.13]), possible sarcopenia (1.80 [1.35-2.45]), and sarcopenia (2.09 [1.48-3.03]) increased in women. The BACES score can estimate HRQOL and associated conditions at antimicrobial treatment initiation in patients with NTM-PD.

Indexed as

Lung DiseasesMycobacterium Infections, NontuberculousQuality of LifeAgedFemaleHand StrengthHumansMaleMiddle AgedNutritional StatusProspective StudiesSurveys and QuestionnairesNontuberculous mycobacteriaNutritional statusPhysical activityQuality of lifeSarcopenia

Identifiers

PMID40683901
PMCPMC12276281

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.