Evidence map›Paper›PMID 40683889›Full record

ArticleBone research2025

Osteoclast-independent osteocyte dendrite defects in mice bearing the osteogenesis imperfecta-causing Sp7 R342C mutation.

Jialiang S Wang, Katelyn Strauss, Caroline Houghton, Numa Islam, Sung-Hee Yoon, Tatsuya Kobayashi, Daniel J Brooks, Mary L Bouxsein, Yingshe Zhao, Cristal S Yee and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jialiang S WangCharles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, USA. jialiang.wang@utsouthwestern.edu.ORCID http://orcid.org/0000-0002-3409-7619
Katelyn StraussEndocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Caroline HoughtonEndocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Numa IslamCharles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Sung-Hee YoonEndocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Tatsuya KobayashiEndocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Daniel J BrooksEndocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Mary L BouxseinEndocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Yingshe ZhaoEndocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Cristal S YeeDepartment of Orthopaedic Surgery, University of California in San Francisco, San Francisco, CA, USA.
Tamara N AllistonDepartment of Orthopaedic Surgery, University of California in San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-9992-2897
Marc N WeinEndocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. mnwein@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-6015-8147

Funding

Tissue Phenotyping CoreP01DK011794 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI JUEPPNER, HARALD W. · 1986 to 2023
$44.4M
The mechanistic control of bone quality and joint crosstalk by osteocytesR01DE019284 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HERNANDEZ, CHRISTOPHER JOHN · 2009 to 2024
$7.6M
Translational Imaging and Phenotyping CoreP30AR075042 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI Marie Demay · 2019 to 2026
$7.4M
The role of salt inducible kinases in parathyroid hormone action in boneR01DK116716 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Marc Nathan Wein · 2018 to 2026
$3.8M
Skeletal Phenotyping CoreP30AR066261 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI KRONENBERG, HENRY M. · 2014 to 2018
$3.5M
Comprehensive investigation of SP7 during the osteoblast-to-osteocyte transitionR00AR081897 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI Jialiang Wang · 2024 to 2026
$717k
Comprehensive investigation of SP7 during the osteoblast-to-osteocyte transitionK99AR081897 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI WANG, JIALIANG · 2023 to 2024
$186k
NIAMS NIH HHS K99 AR081897NIAMS NIH HHS P30 AR075042NIAMS NIH HHS R00 AR081897NIDCR NIH HHS R01 DE019284U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) K99AR081897U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) P30AR066261U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) P30AR075042U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R00AR081897U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) P01DK011794U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK116716
6 · The paper itself

Abstract

Osteogenesis imperfecta (OI) is a group of diseases caused by defects in type I collagen processing which result in skeletal fragility. While these disorders have been regarded as defects in osteoblast function, the role of matrix-embedded osteocytes in OI pathogenesis remains largely unknown. Homozygous human SP7 (c.946 C > T, R316C) mutation results in a recessive form of OI characterized by fragility fractures, low bone mineral density and osteocyte dendrite defects. To better understand how the OI-causing R316C mutation affects the function of SP7, we generated Sp7

Indexed as

DendritesMutationOsteoclastsOsteocytesOsteogenesis ImperfectaSp7 Transcription FactorAnimalsApoptosisBone DensityBone RemodelingHumansMiceOsteoblastsSp7 Transcription Factor

Identifiers

PMID40683889
PMCPMC12276330

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.