Evidence map›Paper›PMID 40683857›Full record

ArticleNature communications2025

Prdm16 regulates the postnatal fate of embryonic radial glia via Vcam1-dependent mechanisms.

Jiwen Li, Marlesa I Godoy, Yi Lu, Alice J Zhang, Graciel Diamante, Elle Rathbun, Min Tian, In Sook Ahn, Arantxa Cebrian-Silla, Arturo Alvarez-Buylla and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Jiwen Li *Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
Marlesa I Godoy *Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles (UCLA), Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-7012-1612
Yi Lu *Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles (UCLA), Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-0306-2621
Alice J ZhangDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
Graciel DiamanteDepartment of Integrative Biology and Physiology, UCLA, Los Angeles, CA, USA.
Elle RathbunDepartment of Neurology, UCLA, Los Angeles, CA, USA.
Min TianDepartment of Neurology, UCLA, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-0460-4584
In Sook AhnDepartment of Integrative Biology and Physiology, UCLA, Los Angeles, CA, USA.
Arantxa Cebrian-SillaEli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Arturo Alvarez-BuyllaEli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Xia YangDepartment of Integrative Biology and Physiology, UCLA, Los Angeles, CA, USA.
Bennett G NovitchBrain Research Institute at UCLA, Los Angeles, CA, USA.
S Thomas CarmichaelDepartment of Neurology, UCLA, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-1169-9203
Ye ZhangDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles (UCLA), Los Angeles, CA, USA. yezhang@ucla.edu.ORCID http://orcid.org/0000-0002-1546-5930

Funding

UCLA IDDRC: Translational CoreP50HD103557 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUSAN Y BOOKHEIMER · 2020 to 2026
$9.6M
Molecular characterization of reactive astrocytes in humansR01NS109025 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, YE · 2018 to 2022
$1.7M
Identification of transcription factors that regulate astrocyte differentiationR00NS089780 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, YE · 2017 to 2019
$745k
NICHD NIH HHS P50 HD103557NINDS NIH HHS R00 NS089780NINDS NIH HHS R01 NS109025
6 · The paper itself

Abstract

The mammalian brain undergoes rapid and extensive neurogenesis during the embryonic stage and limited neurogenesis during the adult stage, which results in ineffective repair of neural circuits in adults. Currently, the molecular mechanisms regulating the postnatal termination of neurogenesis and the disappearance of embryonic radial glia, the neural stem cells (NSCs) responsible for neurogenesis, are largely unknown. Here, we show that genetic deletion of PR domain-containing 16 (Prdm16) from NSCs leads to the retention of radial glia in adulthood and prolonged postnatal neuroblast production. Mechanistically, Prdm16 induces a postnatal reduction in Vascular Cell Adhesion Molecule 1 (Vcam1). The extended presence of radial glia and neurogenesis phenotype is rescued in Prdm16-Vcam1 double knockout mice. These findings demonstrate that the inhibition of Vcam1 by Prdm16 promotes the postnatal cessation of neurogenesis and the disappearance of embryonic radial glia and provide valuable insights for regenerative medicine aimed at treating central nervous system disorders.

Indexed as

DNA-Binding ProteinsEpendymoglial CellsNeural Stem CellsNeurogenesisTranscription FactorsVascular Cell Adhesion Molecule-1AnimalsBrainFemaleMaleMiceMice, Inbred C57BLMice, KnockoutNeurogliaDNA-Binding ProteinsPrdm16 protein, mouseTranscription FactorsVascular Cell Adhesion Molecule-1

Identifiers

PMID40683857
PMCPMC12276310

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.