Evidence map›Paper›PMID 40683634›Full record

ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2025

A Novel 3D-Printed Mouse Model for Surgical Training: Multicenter Construct, Face, and Content Validation Study.

Diego Celdran-Bonafonte, Felix Gantenbein, Daniel Ruiz Perez, Regina Rumpel, Nina Eva Trimmel

Abstract read
In one paragraph

Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Diego Celdran-Bonafonte1University Animal Care, The University of Arizona, Tucson, Arizona.
Felix Gantenbein2Zurich Integrative Rodent Physiology, Institute of Physiology, University of Zurich, Zurich, Switzerland.
Daniel Ruiz Perez3Biomedical Research Facility, Royal College of Surgeons in Ireland, Dublin, Ireland.
Regina Rumpel4Institute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany; and.
Nina Eva Trimmel5Center for Medical Research, Faculty of Medicine, Johannes Kepler University, Linz, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advancements in laboratory animal training increasingly incorporate technological innovations aiming to better align training standards with the 3Rs (Replacement, Reduction, and Refinement). This trend is shifting away from traditional reliance on live animals and cadavers toward simulation-based methods. This study introduces and assesses the validity of a novel 3D-printed rodent surgical simulator designed for the practice and training of basic rodent surgical skills. To evaluate its potential to partially replace animal use, refine rodent surgical training, and reduce the number of animals needed, a multicenter validation study across 5 European and US research academic centers was conducted. The study assessed the simulator's face, content, and construct validity, involving participants inexperienced and experts in rodent surgery. The construct validity was evaluated through task completion times and blinded quality assessments across multiple training iterations. The results revealed that inexperienced participants demonstrated significant improvements in both speed and quality of surgical tasks with repeated simulator use, eventually reaching performance levels comparable to experts' initial attempts. Expert participants consistently outperformed the inexperienced group. Face and content validity were supported by postuse surveys, with high ratings from both groups regarding the simulator's anatomic realism and its perceived usefulness for the acquisition and development of fundamental surgical skills. Overall, the findings of this study support that this 3D-printed rodent surgical simulator offers a realistic, effective, and ethically sound alternative for basic rodent surgical skills training and competency assessment.

Identifiers

PMID40683634
PMCPMC12532121

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.