Evidence map›Paper›PMID 40683453›Full record

ArticleMucosal immunology2025

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling.

Sara Alonso, Harsimran Kaur, Luo Jia, Mai-Uyen Nguyen, Alyssa Laguerta, Andrew Fong, Neema Skariah, Rafael J Argüello, Michael P Verzi, Mahima Swamy and 2 more

Abstract read
In one paragraph

Article in Mucosal immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Sara AlonsoCenter for Immunity and Inflammation, Department of Pathology, Immunology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA; Department of Pathology, Molecular and Cell-Based Medicine and Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Harsimran KaurProgram in Chemical and Physical Biology, Department of Cell and Developmental Biology, Center for Computational Systems Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Luo JiaCenter for Immunity and Inflammation, Department of Pathology, Immunology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.
Mai-Uyen NguyenDepartment of Genetics, Human Genetics Institute of New Jersey, Rutgers, The State University of New Jersey, Piscataway, NJ, USA; Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.
Alyssa LaguertaCenter for Immunity and Inflammation, Department of Pathology, Immunology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.
Andrew FongDepartment of Pathology, Molecular and Cell-Based Medicine and Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Neema SkariahMedical Research Council Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Rafael J ArgüelloCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, CNRS, INSERM, Marseille, France; GammaOmics, Marseille, France.
Michael P VerziDepartment of Genetics, Human Genetics Institute of New Jersey, Rutgers, The State University of New Jersey, Piscataway, NJ, USA; Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.
Mahima SwamyMedical Research Council Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Ken S LauProgram in Chemical and Physical Biology, Department of Cell and Developmental Biology, Center for Computational Systems Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Karen L EdelblumCenter for Immunity and Inflammation, Department of Pathology, Immunology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA; Department of Pathology, Molecular and Cell-Based Medicine and Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: karen.edelblum@mssm.edu.

Funding

Understanding and Controlling p120 Dysfunction in CRCP50CA095103 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COFFEY, ROBERT J. · 2002 to 2017
$33.6M
Tuft cell heterogeneity in function, lineage, and structure in ileal inflammatory diseaseR01DK103831 · NIDDK · VANDERBILT UNIVERSITY · PI LAU, KEN S · 2016 to 2024
$4.4M
Mechanisms Driving Metabolic Shifts in the Intestinal EpitheliumR01DK126446 · NIDDK · RUTGERS, THE STATE UNIV OF N.J. · PI VERZI, MICHAEL P. · 2021 to 2025
$2.1M
CD39 in gamma delta intraepithelial lymphocyte functionR01DK141146 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Karen Leigh Edelblum · 2024 to 2026
$2.0M
Interferon regulation of gamma delta intraepithelial lymphocyte activationR01DK119349 · NIDDK · RBHS-NEW JERSEY MEDICAL SCHOOL · PI EDELBLUM, KAREN LEIGH · 2019 to 2023
$1.8M
BD FACSAria II for NJMS Flow Cytometry CoreS10RR027022 · NCRR · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI FITZGERALD-BOCARSLY, PATRICIA · 2011 to 2011
$501k
Microbiota-gamma delta IEL-Paneth cell axis in host antimicrobial responseR21AI171959 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI EDELBLUM, KAREN LEIGH · 2022 to 2023
$439k
NCI NIH HHS P50 CA095103NCRR NIH HHS S10 RR027022NIAID NIH HHS R21 AI171959NIDDK NIH HHS R01 DK103831NIDDK NIH HHS R01 DK119349NIDDK NIH HHS R01 DK126446NIDDK NIH HHS R01 DK141146Wellcome Trust
6 · The paper itself

Abstract

Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mice harboring a microbiota-specific hyperproliferative γδ IEL (γδ

Indexed as

Antigens, CDApyraseGastrointestinal MicrobiomeInterleukin-15Intestinal MucosaIntraepithelial LymphocytesReceptors, Antigen, T-Cell, gamma-deltaAnimalsLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutSignal TransductionAntigens, CDApyraseCD39 antigenInterleukin-15Receptors, Antigen, T-Cell, gamma-delta

Identifiers

PMID40683453
PMCPMC12363992

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.