Evidence map›Paper›PMID 40683251›Full record

ArticleDevelopmental cell2025

Disruption of E-cadherin in the airway led to dysplastic stressed cells and asthma-like phenotypes.

Randee E Young, Sunyoung Lee, Jisun Chin, Barsha Dash, Jugraj Sahi, Leah B Nantie, Yujuan Su, Rebecca J Salamon, Jamie M Verheyden, Justinn Barr and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Randee E YoungDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI 53706, USA.
Sunyoung LeeDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Department of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Jisun ChinDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
Barsha DashDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
Jugraj SahiDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
Leah B NantieLaboratory of Genetics, University of Wisconsin-Madison, Madison, WI 53706, USA.
Yujuan SuDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
Rebecca J SalamonDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
Jamie M VerheydenDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
Justinn BarrDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
Jae Woo ShinLa Jolla Institute of Immunology, La Jolla, CA 92093, USA.
Andrew S H DayDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
Pandurangan VijayanandLa Jolla Institute of Immunology, La Jolla, CA 92093, USA.
Nabora Reyes de BarbozaDepartment of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Xin SunDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: xinsun@ucsd.edu.

Funding

Mechanosensor Function in the Control of Gas Exchange Surface Size and CompositionR01HL169853 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Xin Sun · 2023 to 2026
$2.2M
Impact of Early-in-life Disruption of Lung Development on Adult Lung Progenitor FunctionR01HL143256 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PRINCE, LAWRENCE S, SUN, XIN · 2018 to 2021
$2.1M
Balancing Airway Progenitor versus Progeny: a Pathway from MitochondriaR01HL160019 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUN, XIN · 2021 to 2024
$2.1M
NHLBI NIH HHS R01 HL143256NHLBI NIH HHS R01 HL160019NHLBI NIH HHS R01 HL169853
6 · The paper itself

Abstract

While E-cadherin is a known core component of the adherens junction, how it controls cell fate remains poorly understood. Here, we show that in the mouse airway, inactivation of E-cadherin in epithelial progenitor club cells, but not terminally differentiated ciliated cells, led to increased proliferation, goblet cell metaplasia, and immune infiltration, mimicking asthma phenotypes without exposure to allergen. Single-cell RNA sequencing identified a cellular stress signature in the mutant airway; a profile previously associated with dysplastic alveolar transitional cells in fibrotic lungs. Chemokine genes such as Cxcl17 are upregulated in the mutant airway both in vivo and when cultured in isolation, identifying an intrinsic ability of the epithelium to sense junction breach and launch immune defense. Inactivation of Il4ra in the mutant attenuated goblet cell metaplasia, but not immune recruitment. Together, these findings demonstrate that loss of E-cadherin leads to airway remodeling through both an epithelium-intrinsic mechanism and epithelium-immune crosstalk.

Indexed as

AsthmaCadherinsAirway RemodelingAnimalsCell ProliferationEpithelial CellsGoblet CellsLungMetaplasiaMiceMice, Inbred C57BLPhenotypeCadherinsCdh1 protein, mouseasthmadysplastic alveolar transitional cellsE-cadherinimmune responselung epithelium

Identifiers

PMID40683251
PMCPMC12978819

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.