Evidence map›Paper›PMID 40682849›Full record

ArticleOncology reports2025

Chromosome 20q gene signature associated with colorectal cancer progression.

Jennifer Carter Jones, Apurva M Hegde, Yu-Jing Huang, Ganiraju Manyam, Vibhuti Srivastava, Jee Hoo Song, Yulan Cheng, Ralf Krahe, Warapen Treekitkarnmongkol, Stephen J Meltzer and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jennifer Carter Jones *Department of Translational Molecular Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Apurva M Hegde *Program in Human and Molecular Genetics, The University of Texas Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
Yu-Jing HuangDepartment of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Ganiraju ManyamDepartment of Bioinformatics and Computational Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Vibhuti SrivastavaDepartment of Translational Molecular Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Jee Hoo SongDepartment of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Yulan ChengDepartment of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Ralf KraheProgram in Human and Molecular Genetics, The University of Texas Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
Warapen TreekitkarnmongkolDepartment of Translational Molecular Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Stephen J MeltzerDepartment of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Scott KopetzDepartment of Gastrointestinal Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Stanley R HamiltonProgram in Human and Molecular Genetics, The University of Texas Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
Hiroshi KatayamaDepartment of Translational Molecular Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Subrata SenDepartment of Translational Molecular Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

Funding

Novel human oncogene STK15/BTAK/Aurora 2R01CA089716 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SEN, SUBRATA · 2001 to 2012
$2.3M
NCI NIH HHS R01 CA089716
6 · The paper itself

Abstract

Amplification of human chromosome 20q has been reported as the most frequently recurring genetic abnormality associated with large scale changes in mRNA and protein levels in sporadic colorectal carcinomas. While some studies have found 20q amplification to be consistent between primary and metastatic samples from the same patient with a role in the development of metastasis and worse patient prognosis, others have reported association with improved overall survival for a subset of these patients with colorectal cancer (CRC). To fine map the Minimal Common Regions (MCRs) of amplification on chromosome 20q and identify the candidate genes playing roles in progression of the disease, microarray comparative genomic hybridization analyses of two

Indexed as

AdenocarcinomaBiomarkers, TumorChromosomes, Human, Pair 20Colorectal NeoplasmsLiver NeoplasmsAgedCell Line, TumorComparative Genomic HybridizationDisease ProgressionFemaleGene AmplificationGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMaleMiddle AgedBiomarkers, TumorCGHchromosome 20qCRC progressiongene signatureRT‑qPCRSKY

Identifiers

PMID40682849
PMCPMC12308843

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.