ReviewInternational journal of molecular medicine2025
Emerging threat of environmental microplastics: A comprehensive analysis of hepatic metabolic dysregulation and hepatocellular damage (Review).
Review in International journal of molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Network toxicology and molecular docking reveal the mechanistic basis of bisphenol A-mediated cholestatic liver injury.Toxicology reports · 2026Article
- Microplastics, nanoplastics and liver disease: an emerging health concern?Nature reviews. Gastroenterology & hepatology · 2026Review
- Micro- and Nanoplastics as Emerging Drivers of Liver Injury: Exposure, Evidence, and Mechanisms.International journal of molecular sciences · 2026Review
- Review
- Pathogenesis of Micro/Nanoplastics in Mammalian Systems: Gut to Systemic Multi-Organ Dysfunction.Research (Washington, D.C.) · 2026Review
- Chronic PET-Microplastic Exposure: Disruption of Gut-Liver Homeostasis and Risk of Hepatic Steatosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Microplastics, Endocrine Disruptors, and Oxidative Stress: Mechanisms and Health Implications.International journal of molecular sciences · 2025Review
- Microplastics in metabolic dysfunction-associated steatotic liver disease: An emerging threat to liver health.World journal of hepatology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The substantial rise in global plastic production has led to the widespread accumulation of microplastics (MPs) in the soil, water and atmosphere. Inevitably, animals and humans have ingested these MPs through environmental contact, resulting in their accumulation within the liver. The elucidation of the hepatotoxic effects of MPs in animals, and in particular on human liver pathophysiology, is now a central topic of investigation in the study of environmental particulate toxicology. The present review summarised existing studies on how MPs damage the liver, and in particular, highlighted the mechanisms of action and the key influencing factors. There is evidence that indicates that MPs can damage the liver tissue structure, induce liver cell death and disrupt lipid metabolism, and that particle size and exposure time are important factors influencing the adverse effects of MPs on the liver. However, further research is required to comprehensively elucidate the mechanisms by which MPs induce liver injury and the long‑term health risks they pose.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.